Faculty

• UJIIE Hideyuki

  Professor and Chair

  Fields of specialty

  Autoimmune blistering diseases, Atopic dermatitis, Skin immunology

  More

  Certification

  Board Certification by Japanese Dermatological Association

  Professional Societies

  The Japanese Dermatological Association (Delegate and Guideline Committee Member)
  The Japanese Society for Investigative Dermatology (Councilor)
  Japan Organization of Clinical Dermatologists
  Japanese Society for Immunology
  Japanese Society of Allergology (Hokkaido Branch Councilor)
  The Japanese Society for Cutaneous Immunology and Allergy
  Japanese Society for Psoriasis Research (Councilor)
  Society for Investigative Dermatology
  European Society for Dermatological Research

  Education and professional experience

  2002 Mar M.D., Hokkaido University School of Medicine
  2002 May Resident, Dermatology Dept., Hokkaido Univ. Hospital
  2005 Apr Resident, Dermatology Dept., Hokkaido Cancer Center
  2010 Mar Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2010 Apr Assistant professor, Dermatology Dept., Hokkaido Univ. Hospital
  2012 Sep Visiting fellow, National Institutes of Health (NIH) (Ethan Shevach Lab., USA)
  2013 Apr JSPS Overseas Research Fellowship
  2014 Sep Assistant professor, Dermatology Dept., Hokkaido Univ. Hospital
  2016 Sep Associate professor, Dermatology Dept., Hokkaido Univ. Hospital
  2021 Jan Professor and chairman, Dermatology Dept., Faculty of Medicine and Graduate School of Medicine Hokkaido University

  Major Publications

  1. Muramatsu K, Zheng M, Yoshimoto N, Ito T, Ujiie I, Iwata H, Shimizu H, Ujiie H:
     Regulatory T cell subsets in bullous pemphigoid and dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid.
     J Dermatol Sci 100: 23-30, 2020.
  2. Ujiie H, Iwata H, Yamagami J, Nakama T, Aoyama Y, Ikeda S, Ishii N, Iwatsuki K, Kurosawa M, Sawamura D, Tanikawa A, Tsuruta D, Nishie W, Fujimoto W, Amagai M, Shimizu H, Committee for Guidelines for the Management of Pemphigoid Diseases (Including Epidermolysis Bullosa Acquisita):
     Japanese guidelines for the management of pemphigoid (including epidermolysis bullosa acquisita).
     J Dermatol 46: 1102-1135, 2019.
  3. Ujiie H, Yoshimoto N, Natsuga K, Muramatsu K, Iwata H, Nishie W, Shimizu H:
     Immune reaction to type XVII collagen induces intramolecular and intermolecular epitope spreading in experimental bullous pemphigoid models.
     Front Immunol 10: 1410, 2019.
  4. Ujiie I, Ujiie H, Iwata H, Shimizu H:
     Clinical and immunological features of pemphigus relapse.
     Br J Dermatol 180: 1498-1505, 2019.
  5. Muramatsu K, Ujiie H, Kobayashi I, Nishie W, Izumi K, Ito T, Yoshimoto N, Natsuga K, Iwata H, Shimizu H:
     Regulatory T-cell dysfunction induces autoantibodies to bullous pemphigoid antigens in mice and human subjects.
     J Allergy Clin Immunol 142: 1818-1830, 2018.
  6. Ujiie H, Muramatsu K, Mushiroda T, Ozeki T, Miyoshi H, Iwata H, Nakamura A, Nomoto H, Cho KY, Sato N, Nishimura M, Ito T, Izumi K, Nishie W, Shimizu H:
     HLA-DQB1*03:01 as a biomarker for genetic susceptibility to bullous pemphigoid induced by DPP-4 inhibitors.
     J Invest Dermatol 138: 1201-1204, 2018.
  7. Sasaoka T^#, Ujiie H^#, Nishie W, Iwata H, Ishikawa M, Higashino H, Natsuga K, Shinkuma S, Shimizu H:
     Intravenous IgG reduces pathogenic autoantibodies, serum IL-6 levels, and disease severity in experimental bullous pemphigoid models.
     J Invest Dermatol 138: 1260-1267, 2018. ^# co-first author
  8. Ujiie H, Shevach EM:
     gdT cells protect liver and lung of mice from the autoimmunity induced by scurfy lymphocytes.
     J Immunol 196: 1517-1528, 2016.
  9. Ujiie H, Sasaoka T, Izumi K, Nishie W, Shinkuma S, Natsuga K, Nakamura H, Shibaki A, Shimizu H:
     Bullous pemphigoid autoantibodies directly induce blister formation without complement activation.
     J Immunol 193: 4415-4428, 2014.
  10. Ujiie H, Shibaki A, Nishie W, Sawamura D, Wang G, Tateishi Y, Li Q, Moriuchi R, Qiao H, Nakamura H, Akiyama M, Shimizu H:
      A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen.
      J Immunol 184: 2166-2174, 2010.

  Publication Lists (PubMed)

• NATSUGA Ken

  Senior Associate Professor

  Fields of specialty

  Epidermolysis bullosa, Psoriasis, Epidermal stem cells

  More

  Certification

  Ph.D., Hokkaido University Graduate School of Medicine, Japan (2010)
  Board Certification by Japanese Dermatological Association (2008)
  M.D., Hokkaido University School of Medicine, Japan (2003)

  Professional Societies

  The Japanese Dermatological Association
  The Japanese Society for Investigative Dermatology (Junior Board Director)
  Japan Organization of Clinical Dermatologists
  European Society for Dermatological Research
  Society for Investigative Dermatology
  Japan Skin Research Club (Organizer)

  Education and professional experience

  2003 Mar M.D., Hokkaido University School of Medicine
  2003 Mar Resident, Dermatology Dept., Hokkaido Univ. Hospital
  2005 Apr Resident, Dermatology Dept., Hokkaido Cancer Center
  2006 Apr Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2010 Mar Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2010 Sep Visiting Scientist, Cancer Research UK Cambridge Research Institute (Fiona Watt Lab., UK)
  2011 Apr JSPS Overseas Research Fellowship
  2012 Sep Assistant professor, Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2016 Aug Associate professor, Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2021 Feb Senior associate professor, Dermatology Dept., Faculty of Medicine and Graduate School of Medicine Hokkaido University
  2021 Apr Senior associate professor, Research Institute for Electronic Science, Hokkaido University

  Major Publications

  1. Natsuga K, Furuta Y, Takashima S, Nohara S, Kosumi H, Mai Y, Higashi H, Ujiie H:
     Detection of revertant mosaicism in epidermolysis bullosa through Cas9-targeted long read sequencing.
     Hum Mutat 43: 529-536, 2022.
  2. Wang Y, Kitahata H, Kosumi H, Watanabe M, Fujimura Y, Takashima S, Osada SI, Hirose T, Nishie W, Nagayama M, Shimizu H, Natsuga K:
     Collagen XVII deficiency alters epidermal patterning.
     Lab Invest 102: 581-588, 2022.
  3. Kosumi H, Watanabe M, Shinkuma S, Fujimura Y, Tsukiyama T, Donati G, Iwata H, Ujiie H, Natsuga K:
     Wnt/beta-catenin signaling stabilizes hemidesmosomes in keratinocytes.
     J Invest Dermatol 142: 1576-1586, 2022.
  4. Fujimura Y, Watanabe M, Ohno K, Kobayashi Y, Takashima S, Nakamura H, Kosumi H, Wang Y, Mai Y, Lauria A, Proserpio V, Ujiie H, Iwata H, Nishie W, Nagayama M, Oliviero S, Donati G, Shimizu H, Natsuga K:
     Hair follicle stem cell progeny heal blisters while pausing skin development.
     EMBO Rep 22: e50882, 2021.
  5. Watanabe M, Natsuga K, Nishie W, Kobayashi Y, Donati G, Suzuki S, Fujimura Y, Ujiie H, Shinkuma S, Nakamura H, Murakami M, Ozaki M, Nagayama M, Watt FM, Shimizu H:
     Type XVII collagen coordinates proliferation in the interfollicular epidermis.
     Elife 6: e26635, 2017.
  6. Natsuga K, Cipolat S, Watt FM:
     Increased bacterial load and expression of antimicrobial peptides in skin of barrier-deficient mice with reduced cancer susceptibility.
     J Invest Dermatol 136: 99-106, 2016.
  7. Natsuga K, Nishie W, Shinkuma S, Ujiie H, Nishimura M, Sawamura D, Shimizu H:
     Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and -independent manner.
     J Immunol 188: 5792-5799, 2012.
  8. Natsuga K, Nishie W, Smith BJ, Shinkuma S, Smith TA, Parry DA, Oiso N, Kawada A, Yoneda K, Akiyama M, Shimizu H:
     Consequences of two different amino-acid substitutions at the same codon in KRT14 endicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis.
     J Invest Dermatol 131: 1869-1876, 2011.
  9. Natsuga K, Nishie W, Akiyama M, Nakamura H, Shinkuma S, McMillan JR, Nagasaki A, Has C, Ouchi T, Ishiko A, Hirako Y, Owaribe K, Sawamura D, Bruckner-Tuderman L, Shimizu H:
     Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex.
     Hum Mutat 31: 308-316, 2010.
  10. Natsuga K, Akiyama M, Shimizu T, Suzuki T, Ito S, Tomita Y, Tanaka J, Shimizu H:
      Ultrastructural features of trafficking defects are pronounced in melanocytic nevus in Hermansky-Pudlak syndrome type 1.
      J Invest Dermatol 125: 154-158, 2005.

  Publication Lists (PubMed)

• YANAGI Teruki

  Associate professor

  Fields of specialty

  Skin cancers

  More

  Certification

  Board Certification by Japanese Dermatological Association

  Professional Societies

  The Japanese Dermatological Association
  The Japanese Society for Investigative Dermatology (Councilor)
  Japanese Cancer Association

  Education and professional experience

  2003 Mar M.D., Hokkaido University School of Medicine
  2003 May Resident, Dermatology Dept., Hokkaido Univ. Hospital
  2005 Apr Medical staff, Dermatology Dept., Tonan Hospital
  2006 Apr Resident, Dermatology Dept., Hokkaido Cancer Center
  2010 Mar Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2011 Apr JSPS Research Fellowship for Young Scientists
  2013 Apr JSPS Overseas Research Fellowship
  Sanford-Burnham Medical Research Institute (John C. Reed lab., USA）
  2015 Apr Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2016 Apr Specially appointed Assistant professor, Dermatology Dept., Faculty of Medicine and Graduate School of Medicine Hokkaido University
  2019 Apr Assistant professor, Dermatology Dept., Hokkaido Univ. Hospital
  2021 Apr Associate professor, Dermatology Dept., Hokkaido Univ. Hospital

  Major Publications

  1. Maeda T, Kitamura S, Nishihara H, Yanagi T:
     Extramammary Paget’s disease patient-derived xenografts harboring ERBB2 S310F mutation show sensitivity to HER2-targeted therapies.
     Oncogene 39: 5867-5875, 2020.
  2. Maeda T, Kitamura S, Yanagi T:
     RANK-RANKL signaling pathway contributes to disease progression in cutaneous angiosarcoma: A case report with an immunohistochemical review and in vitro experiments.
     J Eur Acad Dermatol Venereol 34: e834-e837, 2020.
  3. Yanagi T, Kitamura S, Imafuku K, Suto A, Maeda T, Tanaka S, Sesaki H, Abe R, Shimizu H:
     Loss of dynamin-related protein 1 (Drp1) does not affect epidermal development or UVB-induced apoptosis but does accelerate UVB-induced carcinogenesis.
     J Dermatol Sci 99: 109-118, 2020.
  4. Yanagi T, Watanabe M, Hata H, Kitamura S, Imafuku K, Yanagi H, Homma A, Wang L, Takahashi H, Shimizu H, Hatakeyama S:
     Loss of TRIM29 alters keratin distribution to promote cell invasion in squamous cell carcinoma.
     Cancer Res 78: 6795-6806, 2018.
  5. Yanagi T, Hata H, Mizuno E, Kitamura S, Imafuku K, Nakazato S, Wang L, Nishihara H, Tanaka S, Shimizu H:
     PCTAIRE1/CDK16/PCTK1 is overexpressed in cutaneous squamous cell carcinoma and regulates p27 stability and cell cycle.
     J Dermatol Sci 86: 149-157, 2017.
  6. Yanagi T, Tachikawa K, Wilkie-Grantham R, Hishiki A, Nagai K, Toyonaga E, Chivukula P, Matsuzawa SI:
     Lipid nanoparticle-mediated siRNA transfer Against PCTAIRE1/PCTK1/Cdk16 inhibits in vivo cancer growth.
     Mol Ther Nucleic Acids 5: e327, 2016.
  7. Yanagi T, Krajewska M, Matsuzawa S, Reed JC:
     PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells.
     Cancer Res 74; 5795-5807, 2014.
  8. Yanagi T, Akiyama M, Nishihara H, Ishikawa J, Sakai K, Miyamura Y, Naoe A, Kitahara T, Tanaka S, Shimizu H:
     Self-improvement of keratinocyte differentiation defects during skin maturation in ABCA12 deficient harlequin ichthyosis model mice.
     Am J Pathol 177: 106-118, 2010.
  9. Yanagi T, Akiyama M, Sakai K, Nagasaki A, Ozawa N, Kosaki R, Sago H, Shimizu H:
     DNA-based prenatal exclusion of harlequin ichthyosis.
     J Am Acad Dermatol 58: 653-656, 2008.
  10. Yanagi T, Akiyama M, Nishihara H, Sakai K, Nishie W, Tanaka S, Shimizu H.
      Harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal skin barrier defects.
      Hum Mol Genet 17: 3075-3083, 2008.

  Publication Lists (PubMed)

• IZUMI Kentaro

  Associate professor

  Fields of specialty

  Autoimmune blistering diseases, Atopic dermatitis

  More

  Certification

  Board Certification by Japanese Dermatological Association

  Society

  The Japanese Dermatological Association
  The Japanese Society for Investigative Dermatology

  Education and professional experience

  2006 Mar M.D., Asahikawa Medical University School of Medicine
  2006 Apr Junior Resident, Sapporo Higashi Tokushukai Hospital
  2008 Apr Senior Resident, Dermatology Dept., Hokkaido Univ. Hospital
  2010 Apr Medical staff, Dermatology Dept., Kushiro City Hospital
  2011 Apr Medical staff, Dermatology Dept., Hakodate Central General Hospital
  2011 Jul Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2012 Mar Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2016 Oct Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2017 Oct Visiting scientist, University of Lübeck (Detlef Zillikens Lab., Germany)
  2020 Jan Assistant Professor, Dermatology Dept., Faculty of Medicine and Graduate School of Medicine Hokkaido University
  2022 Apr Associate professor, Dermatology Dept., Hokkaido Univ. Hospital

  Major Publications

  1. Hayashi M, Tsunoda T, Sato F, Yaguchi Y, Igarashi M, Izumi K, Nishie W, Ishii N, Okamura K, Suzuki T, Hashimoto T:
     Clinical and immunological characterisation of 14 cases of dipeptidyl peptidase 4 inhibitor-associated bullous pemphigoid: a single centre study.
     Br J Dermatol 182: 806-807, 2020.
  2. Izumi K, Nishie W, Beniko M, Shimizu H:
     A Cross-Sectional Study Comparing the Prevalence of Bullous Pemphigoid Autoantibodies in 275 Cases of Type II Diabetes Mellitus Treated With or Without Dipeptidyl Peptidase-IV Inhibitors.
     Front Immunol 10: 1439, 2019.
  3. Izumi K, Bieber K, Ludwig RJ:
     Current Clinical Trials in Pemphigus and Pemphigoid.
     Front Immunol 10: 978, 2019.
  4. Tuusa J, Lindgren O, Tertsunen HM, Nishie W, Kokkonen N, Huilaja L, Izumi K, Herukka SK, Miettunen J, Shimizu H, Remes AM, Tasanen K:
     BP180 Autoantibodies Target Different Epitopes in Multiple Sclerosis or Alzheimer’s Disease than in Bullous Pemphigoid.
     J Invest Dermatol 139: 293-299, 2019.
  5. Mai Y, Nishie W, Sato K, Hotta M, Izumi K, Ito K, Hosokawa K, Shimizu H:
     Bullous Pemphigoid Triggered by Thermal Burn Under Medication With a Dipeptidyl Peptidase-IV Inhibitor: A Case Report and Review of the Literature.
     Front Immunol 9: 542, 2018.
  6. Izumi K , Nishie W, Mai Y, Ujiie H, Iwata H, Natsuga K, Shimizu H:
     Detection of mucous membrane pemphigoid autoantibodies by full-length BP180 enzyme-linked immunosorbent assay.
     J Dermatol Sci 88: 247-248, 2017.
  7. Toyonaga E, Nishie W, Izumi K, Natsuga K, Ujiie H, Iwata H, Yamagami J, Hirako Y, Sawamura D, Fujimoto W, Shimizu H:
     C-Terminal Processing of Collagen XVII Induces Neoepitopes for Linear IgA Dermatosis Autoantibodies.
     J Invest Dermatol 137: 2552-2559, 2017.
  8. Izumi K, Nishie W, Mai Y, Wada M, Natsuga K, Ujiie H, Iwata H, Yamagami J, Shimizu H:
     Autoantibody profile differentiates between inflammatory and non-inflammatory bullous pemphigoid.
     J Invest Dermatol 136: 2201-2210, 2016.
  9. Wada M, Nishie W, Ujiie H, Izumi K, Iwata H, Natsuga K, Nakamura H, Kitagawa Y, Shimizu H:
     Epitope-dependent pathogenicity of Abs targeting a major bullous pemphigoid autoAg collagen XVII/BP180.
     J Invest Dermatol 136: 938-946, 2016.
  10. Nishie W, Natsuga K, Iwata H, Izumi K, Ujiie H, Toyonaga E, Hata H, Nakamura H, Shimizu H:
      Context-Dependent Regulation of Collagen XVII Ectodomain Shedding in Skin.
      Am J Pathol 185: 1361-1371, 2015.

  Publication Lists (PubMed)

• IMAFUKU Keisuke

  Assistant professor

  Fields of specialty

  Skin barrier, Psoriasis

  More

  Certification

  Board Certification by Japanese Dermatological Association

  Professional Societies

  The Japanese Dermatological Association
  The Japanese Society for Investigative Dermatology
  Japanese Organization of Clinical Dermatologists
  Japanese Society for Psoriasis Research

  Education and professional experience

  2012 Apr M.D., Hokkaido University School of Medicine
  2012 Apr Junior Resident, Kitami Red Cross Hospital
  2013 Apr Junior Resident, Hokkaido Univ. Hospital
  2014 Apr Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2015 Apr Medical staff, Dermatology Dept., Tokyo Metropolitan Cancer and Infectious Diseases Center
  2016 Apr Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2022 Mar Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2022 Apr Assistant Professor, Dermatology Dept., Hokkaido Univ. Hospital

  Major Publications

  1. Imafuku K, Kamaguchi M, Natsuga K, Nakamura H, Shimizu H, Iwata H:
     Zonula occludens-1 demonstrates a unique appearance in buccal mucosa over several layers.z
     Cell Tissue Res 384: 691-702,2021.
  2. Imafuku K, Hata H, Yanagi T, Kitamura S, Inamura Y, Nishimura M, Kitamura S, Moriwaki S, Shimizu H:
     Multiple skin cancers in patients with mycosis fungoides after long-term ultraviolet phototherapy.
     Clin Exp Dermatol 5: 523-526, 2017.
  3. Imafuku K, Yoshino K, Yamaguchi K, Tsuboi Satoshi, Ohara K, Hata H:
     Comment on: ‘Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy’
     Br J Cancer 8: e14, 2017.
  4. Imafuku K, Iwata H, Kamaguchi M, Izumi K, Natsuga K, Ujiie H, Nishie W, Shimizu H:
     Autoantibodies of non-inflammatory bullous pemphigoid hardly deplete type XVII collagen of keratinocytes.
     Exp Dermatol 12: 1171-1174, 2017.
  5. Imafuku K, Hata H, Kitamura S, Yanagi T, Shimizu H:
     Ultrasonographic findings can identify ‘pseudoprogression’ under nivolumab therapy.
     Br J Dermatol 177: 1726-1731, 2017.
  6. Imafuku K, Hata H, Yamaguchi Y, Inamura Y, Kitamura S, Yanagi T, Shimizu H:
     Modified Dufourmentel flap, easy to design and tailor to the defect.
     J Dermatol 1: 68-70, 2017.
  7. Imafuku K, Yoshino K, Ymaguchi K, Tsuboi S, Ohara K, Hata H:
     Nivolumab therapy before vemurafenib administration induces a severe skin rash.
     J Eur Acad Dermatol venereol 3: e169-171, 2017.
  8. Imafuku K, Yoshino K, Ishiwata K, Yamaguchi K, Tsuboi S, Ohara K, Hata H:
     Lymphopenia can be a useful biomarker of adverse events related to vemurafenib.
     J Eur Acad Dermatol Venereol 31: e24-26, 2017.
  9. Imafuku K, Yoshino K, Ishiwata K, Otobe S, Tsuboi S, Ohara K, Hata H:
     A single-institution study examining cutaneous and non-cutaneous melanomas treated with nivolumab.
     J Eur Acad Dermatol Venereol 30: e227-229, 2016.
  10. Imafuku K, Yoshino K, Ishiwata K, Otobe S, Tsuboi S, Ohara K, Hata H:
      Severe rash associated with vemurafenib administration following nivolumab therapy.
      J Eur Acad Dermatol Venereol 30: e84-e86, 2016.

  Publication Lists (PubMed)

• TAKASHIMA Shota

  Assistant professor

  Fields of specialty

  Genetic skin diseases, Epidermolysis bullosa

  More

  Certification

  Board Certification by Japanese Dermatological Association

  Professional Societies

  The Japanese Dermatological Association
  The Japanese Society for Investigative Dermatology
  Society for Investigative Dermatology

  Education and professional experience

  2012 Mar　M.D.,Hokkaido University School of Medicine
  2012 Apr　Junior Resident, Kushiro Red Cross Hospital
  2013 Apr　Junior Resident, Hokkaido Univ. Hospital
  2014 Apr　Medical staff, Chitose City Hospital
  2015 Apr　Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2018 Apr　Medical staff, Chitose City Hospital
  2019 Jun　Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2020 Jul　Visiting Scholar, Dermatology Dept., University of California, San Diego (Bryan Sun lab., U.S.A)
  2022 Aug Assistant Professor, Dermatology Dept., Faculty of Medicine and Graduate School of Medicine Hokkaido University

  Major Publications

  1. Takashima S, Shinkuma S, Fujita Y, Nomura T, Ujiie H, Natsuga K, Iwata H, Nakamura H, Vorobyev A, Abe R, Shimizu H:
     Efficient reframing gene therapy for recessive dystrophic epidermolysis bullosa with CRISPR/Cas9.
     J Invest Dermatol 139, 1711-1721, 2019.
  2. Natsuga K, Furuta Y, Takashima S, Nohara T, Kosumi H, Mai Y, Higashi H, Ujiie H:
     Detection of revertant mosaicism in epidermolysis bullosa through Cas9-targeted long-read sequencing.
     Hum Mutat 43: 529-536, 2022.
  3. Takashima S, Fujita Y, Saito N, Suzuki S, Nomura T, Shimizu H:
     RNA recognition motif of LEMD3 as a key player in the pathogenesis of Buschke-Ollendorff syndrome.
     J Dermatol Sci 81: 205-208, 2016.
  4. Takashima S, Fujita Y, Shinkuma S, Shimizu S, Hasegawa T, Amizuka N, Shimizu H, Natsuga K*:
     Calcinosis cutis in self-healing dominant dystrophic epidermolysis bullosa.
     J Dermatol 47 :e457-8, 2020.
  5. Matsumura W, Fujita Y, Shinkuma S, Suzuki S, Yokoshiki S, Goto H, Hayashi H, Ono K, Inoie M, Takashima S, Nakayama C, Nomura T, Nakamura H, Abe R, Sato N, Shimizu H:
     Cultured epidermal autografts from clinically revertant skin as a potential wound treatment for recessive dystrophic bullosa.
     J Invest Dermatol 139: 2115-24, 2019.
  6. Takashima S, Shinkuma S, Fujita Y, Nomura T, Hida T, Ishikawa S, Nakamura H, Abe R, Shimizu H:
     A novel COL7A1 mutation in a Japanese family with bullous dermolysis of the newborn: Phenotypic variability associated with a COL7A1 mutation within the same family.
     J Dermatol 34: e260-1, 2018.
  7. Takashima S, Nishie W, Morita Y, Osawa R, Iwata H, Fujita Y, Fujimoto K, Shimizu H:
     Eosinophilic pustular folliculitis in a patient with mycosis fungoides.
     J Eur Acad Dermatol Venereol 30: 712-3, 2016.
  8. Takashima S, Iwata H, Sakata M, Osawa R, Nishie W, Shimizu H:
     Widespread erythema ab igne caused by hot bathing.
     J Eur Acad Dermatol Venereol 29: 2259-61, 2015.
  9. Takashima S，Fujita Y，Miyauchi T，Nomura T，Nishie W，Hamaoka S, Shimizu H:
     Dermoscopic observation in adenoma of the nipple.
     J Dermatol 42: 341-2, 2015.
  10. Takashima S, Sakamoto T, Ota M:
      Tumoral calcinosis in chronic renal failure.
      Lancet Diabetes Endocrinol 2: 852, 2014.

  Publication Lists (PubMed)

• WATANABE Mika

  Assistant professor

  Fields of specialty

  Wound healing, Epidermal stem cells, Epidermolysis bullosa

  More

  Certification

  Board Certification by Japanese Dermatological Association

  Professional Societies

  The Japanese Dermatological Association
  The Japanese Society for Investigative Dermatology

  Education and professional experience

  2007 Mar　M.D.,Hokkaido University School of Medicine
  2007 Apr　Resident, Tokyo Metropolitan Bokutoh Hospital
  2009 Apr　Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2011Apr　Senior Resident, Dermatology Dept., Sapporo City General Hospital
  2012 Apr　Medical staff, Dermatology Dept., JR Sapporo Hospital
  2013 Apr　Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2017 Jun　Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2018 Apr　Postdoctral researcher, University of Turin, Molecular biotechnology center (Giacomo Donati Lab, Italy)
  2019 Apr    JSPS Overseas Research Fellowship
  2023 Jan   Assistant Professor, Dermatology Dept., Hokkaido Univ. Hospital

  Major Publications

  1. Kosumi H, Watanabe M, Shinkuma S, Nohara T, Fujimura Y, Tsukiyama T, Donati G, Iwata H, Nakamura H, Ujiie H, Natsuga K:
     Wnt/β-catenin signaling stabilizes hemidesmosomes in keratinocytes.
     J Invest Dermatol, 142: 1576-158, 2022.
  2. Wang Y, Kitahata H, Kosumi H, Watanabe M, Fujimura Y, Takashima S, Osada S-I, Hirose T, Nishie W, Nagayama M, Shimizu H, Natsuga K:
     Collagen XVII deficiency alters epidermal patterning.
     Lab Invest, 102: 581–588, 2022.
  3. Watanabe M, Kosumi H, Osada S-I, Takashima S, Wang Y, Nishie W, Oikawa T, Hirose T, Shimizu H, Natsuga K:
     Type XVII collagen interacts with the aPKC‐PAR complex and maintains epidermal cell polarity.
     Exp Dermatol, 30: 62–67,2021.
  4. Fujimura Y, Watanabe M, Ohno K, Kobayashi Y, Takashima S, Nakamura H, Kosumi H, Wang Y, Mai Y, Lauria A, Proserpio V, Ujiie H, Iwata H, Nishie W, Nagayama M, Oliviero S, Donati G, Shimizu H, Natsuga K:
     Hair follicle stem cell progeny heal blisters while pausing skin development.
     EMBO Rep, 22: e50882, 2021.
  5. Watanabe M, Natsuga K, Shinkuma S, Shimizu H:
     Epidermal aspects of type VII collagen: implications for dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita.
     J Dermatol, 45: 515-521, 2018.
  6. Fujimura Y, Watanabe M, Natsuga K, Shimizu H:
     Acute vascular reaction due to lipo-prostaglandin E1.
     J Eur Acad Dermatol Venereol, 32: e273-e274, 2018.
  7. Kosumi H, Watanabe M, Natsuga K, Miyauchi T, Shiiya C, Ujiie H, Shimizu H:
     Sweet’s syndrome mimicking ANCA-associated vasculitis.
     Am J Med, 131: e241-e242, 2018.
  8. Watanabe M, Natsuga K, Nishie W, Kobayashi Y, Donati G, Suzuki S, Fujimura Y, Ujiie H, Shinkuma S, Nakamura H, Murakami M, Ozaki M, Nagayama M, Watt FM, Shimizu H:
     Type XVII collagen coordinates proliferation in the interfollicular epidermis.
     ELife, 6: e26635, 2017.
  9. Hayashi R, Natsuga K, Watanabe M, Iwata H, Shinkuma S, Ito A, Masui Y, Ito M, Shimomura Y:
     Epidermolysis bullosa acquisita develops in dominant dystrophic epidermolysis bullosa.
     J Invest Dermatol, 136:320-3, 2016.
  10. Watanabe M, Ujiie H, Nishimura K, Kamiyama T, Abe R, Shimizu H:
      Mycosis fungoides associated with splenic infarction and muscle involvement.
      Br J Dermatol, 173; 1100-1102, 2015.

  Publication Lists (PubMed)

Medical Staffs / Residents / Visiting Clinical Doctors

• KENMOTSU Yasuko
• UJIIE Inkin
• TSUJIWAKI Masumi
• MORITA Yusuke
• SUGAI Tatsuro
• HIKICHI Shiori
• MIYAZAWA Hajime
• ITAMOTO Sota
• KUROSAWA Suguru
• NAGATA Yuri

Ph.D. Course Students

• YOSHIMOTO Norihiro
• PEH Jin Teng
• MAI Shoko
• MAEDA Takuya
• TOKUCHI Keiko
• TAKEDA Masae
• WENG Yu
• SHIIYA Chihiro
• NOHARA Takuma
• HSU Che-yuan
• SEO Takashi
• KATAYAMA Sho
• MIYAMOTO Kodai
• KAWAMURA Takuya

Researchers

• ZHENG Miao

Central Research Institute

• NAKAMURA Hideki

Researching Abroad

• ITO Takamasa
• MURAMATSU Ken
• MIYAUCHI Toshinari

Laboratory Technicians

• TANABE Mika
• YAMASHITA Miho
• MATSUYAMA Asuka

Medical Secretaries

• ISHIKAWA Chieko
• TANAKA Ami

Secretaries

• OGAWA Satomi
• KASAI Kanako
• OSUMI Maki

On leave of absence

• TOYONAGA Ellen
• TAKASHIMA Yuka

Professor Emeritus

• OHKAWARA Akira

Visiting Professors

• NOMURA Toshifumi
• IWATA Hiroaki

Assistant Adjunct Professors

• KUMAKIRI Masanobu
• SATO Hidetsugu
• MATSUMURA Kazuko
• SHIMIZU Satoko
• KODAMA Kazuo
• NAKAMURA Hiroyuki
• ITO Kei
• OTA Mitsuhito
• HOSHINA Daichi
• ANAN Takashi
• MIZUNO Osamu
• SUZUKI Shotaro
• FUJITA Yasuyuki
• FUJIMURA Yu
• HOTTA Moeko
• MAYA Yuka