Members of the Department

Faculty

  • UJIIE Hideyuki
    Professor and Chair

    More

    Certification

    Board Certification by Japanese Dermatological Association

    Professional Societies

    The Japanese Dermatological Association (Delegate and Guideline Committee Member)
    The Japanese Society for Investigative Dermatology (Councilor)
    Japan Organization of Clinical Dermatologists
    Japanese Society for Immunology
    Japanese Society of Allergology (Hokkaido Branch Councilor)
    The Japanese Society for Cutaneous Immunology and Allergy
    Japanese Society for Psoriasis Research (Councilor)
    Society for Investigative Dermatology
    European Society for Dermatological Research

    Education and professional experience

    2002 Mar M.D., Hokkaido University School of Medicine
    2002 May Resident, Dermatology Dept., Hokkaido Univ. Hospital
    2005 Apr Resident, Dermatology Dept., Hokkaido Cancer Center
    2010 Mar Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
    2010 Apr Assistant professor, Dermatology Dept., Hokkaido Univ. Hospital
    2012 Sep Visiting fellow, National Institutes of Health (NIH) (Ethan Shevach Lab., USA)
    2013 Apr JSPS Overseas Research Fellowship
    2014 Sep Assistant professor, Dermatology Dept., Hokkaido Univ. Hospital
    2016 Sep Associate professor, Dermatology Dept., Hokkaido Univ. Hospital
    2021 Jan Professor and chairman, Dermatology Dept., Faculty of Medicine and Graduate School of Medicine Hokkaido University

    Major Publications

    1. Muramatsu K, Zheng M, Yoshimoto N, Ito T, Ujiie I, Iwata H, Shimizu H, Ujiie H:
      Regulatory T cell subsets in bullous pemphigoid and dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid.
      J Dermatol Sci 100: 23-30, 2020.
    2. Ujiie H, Iwata H, Yamagami J, Nakama T, Aoyama Y, Ikeda S, Ishii N, Iwatsuki K, Kurosawa M, Sawamura D, Tanikawa A, Tsuruta D, Nishie W, Fujimoto W, Amagai M, Shimizu H, Committee for Guidelines for the Management of Pemphigoid Diseases (Including Epidermolysis Bullosa Acquisita):
      Japanese guidelines for the management of pemphigoid (including epidermolysis bullosa acquisita).
      J Dermatol 46: 1102-1135, 2019.
    3. Ujiie H, Yoshimoto N, Natsuga K, Muramatsu K, Iwata H, Nishie W, Shimizu H:
      Immune reaction to type XVII collagen induces intramolecular and intermolecular epitope spreading in experimental bullous pemphigoid models.
      Front Immunol 10: 1410, 2019.
    4. Ujiie I, Ujiie H, Iwata H, Shimizu H:
      Clinical and immunological features of pemphigus relapse.
      Br J Dermatol 180: 1498-1505, 2019.
    5. Muramatsu K, Ujiie H, Kobayashi I, Nishie W, Izumi K, Ito T, Yoshimoto N, Natsuga K, Iwata H, Shimizu H:
      Regulatory T-cell dysfunction induces autoantibodies to bullous pemphigoid antigens in mice and human subjects.
      J Allergy Clin Immunol 142: 1818-1830, 2018.
    6. Ujiie H, Muramatsu K, Mushiroda T, Ozeki T, Miyoshi H, Iwata H, Nakamura A, Nomoto H, Cho KY, Sato N, Nishimura M, Ito T, Izumi K, Nishie W, Shimizu H:
      HLA-DQB1*03:01 as a biomarker for genetic susceptibility to bullous pemphigoid induced by DPP-4 inhibitors.
      J Invest Dermatol 138: 1201-1204, 2018.
    7. Sasaoka T#, Ujiie H#, Nishie W, Iwata H, Ishikawa M, Higashino H, Natsuga K, Shinkuma S, Shimizu H:
      Intravenous IgG reduces pathogenic autoantibodies, serum IL-6 levels, and disease severity in experimental bullous pemphigoid models.
      J Invest Dermatol 138: 1260-1267, 2018. # co-first author
    8. Ujiie H, Shevach EM:
      gdT cells protect liver and lung of mice from the autoimmunity induced by scurfy lymphocytes.
      J Immunol 196: 1517-1528, 2016.
    9. Ujiie H, Sasaoka T, Izumi K, Nishie W, Shinkuma S, Natsuga K, Nakamura H, Shibaki A, Shimizu H:
      Bullous pemphigoid autoantibodies directly induce blister formation without complement activation.
      J Immunol 193: 4415-4428, 2014.
    10. Ujiie H, Shibaki A, Nishie W, Sawamura D, Wang G, Tateishi Y, Li Q, Moriuchi R, Qiao H, Nakamura H, Akiyama M, Shimizu H:
      A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen.
      J Immunol 184: 2166-2174, 2010.

    Publication Lists (PubMed)

  • NATSUGA Ken
    Senior Associate Professor

    More

    Certification

    Ph.D., Hokkaido University Graduate School of Medicine, Japan (2010)
    Board Certification by Japanese Dermatological Association (2008)
    M.D., Hokkaido University School of Medicine, Japan (2003)

    Professional Societies

    The Japanese Dermatological Association
    The Japanese Society for Investigative Dermatology (Junior Board Director)
    Japan Organization of Clinical Dermatologists
    European Society for Dermatological Research
    Japan Skin Research Club (Organizer)

    Education and professional experience

    2003 Mar M.D., Hokkaido University School of Medicine
    2003 Mar Resident, Dermatology Dept., Hokkaido Univ. Hospital
    2005 Apr Resident, Dermatology Dept., Hokkaido Cancer Center
    2006 Apr Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
    2010 Mar Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
    2010 Sep Visiting Scientist, Cancer Research UK Cambridge Research Institute (Fiona Watt Lab., UK)
    2011 Apr JSPS Overseas Research Fellowship
    2012 Sep Assistant professor, Dermatology Dept., Graduate School of Medicine, Hokkaido University
    2016 Aug Associate professor, Dermatology Dept., Graduate School of Medicine, Hokkaido University
    2021 Feb Senior associate professor, Dermatology Dept., Faculty of Medicine and Graduate School of Medicine Hokkaido University
    2021 Apr Senior associate professor, Research Institute for Electronic Science, Hokkaido University

    Major Publications

    1. Fujimura Y, Watanabe M, Ohno K, Kobayashi Y, Takashima S, Nakamura H, Kosumi H, Wang Y, Mai Y, Lauria A, Proserpio V, Ujiie H, Iwata H, Nishie W, Nagayama M, Oliviero S, Donati G, Shimizu H, Natsuga K:
      Hair follicle stem cell progeny heal blisters while pausing skin development.
      EMBO Rep 22: e50882, 2021.
    2. Natsuga K, Nishie W, Nishimura M, Shinkuma S, Watanabe M, Izumi K, Nakamura H, Hirako Y, Shimizu H:
      Loss of interaction between plectin and type XVII collagen results in epidermolysis bullosa simplex.
      Hum Mutat 38: 1666-1670, 2017.
    3. Watanabe M, Natsuga K, Nishie W, Kobayashi Y, Donati G, Suzuki S, Fujimura Y, Ujiie H, Shinkuma S, Nakamura H, Murakami M, Ozaki M, Nagayama M, Watt FM, Shimizu H:
      Type XVII collagen coordinates proliferation in the interfollicular epidermis.
      Elife 6: e26635, 2017.
    4. Natsuga K, Cipolat S, Watt FM:
      Increased bacterial load and expression of antimicrobial peptides in skin of barrier-deficient mice with reduced cancer susceptibility.
      J Invest Dermatol 136: 99-106, 2016.
    5. Natsuga K, Nishie W, Shinkuma S, Ujiie H, Nishimura M, Sawamura D, Shimizu H:
      Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and -independent manner.
      J Immunol 188: 5792-5799, 2012.
    6. Natsuga K, Nishie W, Smith BJ, Shinkuma S, Smith TA, Parry DA, Oiso N, Kawada A, Yoneda K, Akiyama M, Shimizu H:
      Consequences of two different amino-acid substitutions at the same codon in KRT14 endicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis.
      J Invest Dermatol 131: 1869-1876, 2011.
    7. Natsuga K, Nishie W, Shinkuma S, Arita K, Nakamura H, Ohyama M, Osaka H, Kambara T, Hirako Y, Shimizu H:
      Plectin deficiency leads to both muscular dystrophy and pyloric atresia in epidermolysis bullosa simplex.
      Hum Mutat 31: E1687-1698, 2010.
    8. Natsuga K, Nishie W, Akiyama M, Nakamura H, Shinkuma S, McMillan JR, Nagasaki A, Has C, Ouchi T, Ishiko A, Hirako Y, Owaribe K, Sawamura D, Bruckner-Tuderman L, Shimizu H:
      Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex.
      Hum Mutat 31: 308-316, 2010.
    9. Natsuga K, Akiyama M, Kato N, Sakai K, Sugiyama-Nakagiri Y, Nishimura M, Hata H, Abe M, Arita K, Tsuji-Abe Y, Onozuka T, Aoyagi S, Kodama K, Ujiie H, Tomita Y, Shimizu H:
      Novel ABCA12 mutations identified in two cases of non-bullous congenital ichthyosiform erythroderma associated with multiple skin malignant neoplasia.
      J Invest Dermatol 127: 2669-2673, 2007.
    10. Natsuga K, Akiyama M, Shimizu T, Suzuki T, Ito S, Tomita Y, Tanaka J, Shimizu H:
      Ultrastructural features of trafficking defects are pronounced in melanocytic nevus in Hermansky-Pudlak syndrome type 1.
      J Invest Dermatol 125: 154-158, 2005.

    Publication Lists (PubMed)

  • IWATA Hiroaki
    Associate professor

    More

    Certification

    Board Certification by Japanese Dermatological Association

    Professional Societies

    The Japanese Dermatological Association
    The Japanese Society for Investigative Dermatology (Councilor)
    Japanese Society for Psoriasis Research
    Japanese Society for Vaccinology
    European Society for Dermatological Research

    Education and professional experience

    1999 Mar M.D., Gifu University School of Medicine
    1999 May Resident, Dermatology Dept., Gifu Univ. Hospital
    2000 Feb Resident, Dermatology Dept., Gifu prefectural general medical center
    2002 Jun Medical staff, Dermatology Dept., National Cancer Center Hospital
    2005 Jun Medical staff, Advanced Critical Care Center & Emergency, Gifu Univ. Hospital
    2005 Dec Assistant professor, Dermatology Dept., Gifu University Graduate School of Medicine
    2009 Mar Ph.D., Dermatology Dept., Gifu University Graduate School of Medicine
    2009 Apr Associate professor, Dermatology Dept., Gifu Univ. Hospital
    2010 Apr University of Lübeck (Detlef Zillikens Lab., Germany)
    2013 Oct Specially appointed assistant professor, Dermatology Dept., Faculty of Medicine and Graduate School of Medicine Hokkaido University
    2017 Apr Assistant professor, Dermatology Dept., Hokkaido Univ. Hospital
    2021 Feb Associate professor, Dermatology Dept., Hokkaido Univ. Hospital

    Major Publications

    1. Imafuku K, Kamaguchi M, Natsuga K, Nakamura H, Shimizu H, Iwata H:
      Zonula occludens-1 demonstrates a unique appearance in buccal mucosa over several layers.
      Cell Tissue Res 384: 691-702, 2021.
    2. Hundt JE#, Iwata H#, Pieper M#, Bieber K, Zillikens D, König P, Ludwig RJ:
      Visualization of autoantibodies and neutrophils in vivo identifies novel checkpoints in autoantibody-induced tissue injury.
      Sci Rep 10: 4509, 2020. # co-first author
    3. Iwata H, Kamaguchi M, Ujiie H, Ujiie I, Natsuga K, Nishie W, ShimizuH:
      Fc-binding proteins enhance autoantibody-induced BP180 depletion in pemphigoid.
      J Pathol 247: 371-380, 2019.
    4. Kamaguchi M, Iwata H, Nishie W, Toyonaga E, Ujiie H, Natsuga K, Kitagawa Y, Shimizu H:
      The direct binding of collagen XVII and collagen IV is disrupted by pemphigoid autoantibodies.
      Lab Invest 99: 48-57, 2019.
    5. Kamaguchi M, Iwata H, Ujiie H, Natsuga K, Nishie W, Kitagawa Y, Shimizu H:
      High Expression of Collagen XVII Compensates for Its Depletion Induced by Pemphigoid IgG in the Oral Mucosa.
      J Invest Dermatol 138: 1707-1715, 2018.
    6. Kamaguchi M, Iwata H, Mori Y, Toyonaga E, Ujiie H, Kitagawa Y, Shimizu H:
      Anti-idiotypic antibodies against BP-IgG prevent type XVII collagen depletion.
      Front Immunol 8: 1669, 2017.
    7. Iwata H, Kamaguchi M, Ujiie H, Nishimura M, Izumi K, Natsuga K, Shinkuma S, Nishie W, Shimizu H:
      Macropinocytosis of type XVII collagen induced by bullous pemphigoid IgG is regulated by protein kinase C.
      Lab Invest 96: 1301-1310, 2016.
    8. Iwata H, Witte M, Samavedam UK, Gupta Y, Shimizu A, Ishiko A, Schröder T, Seeger K, Dahlke M, Rades D, Zillikens D and Ludwig RJ:
      Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita.
      J Immunol 195: 1945-54, 2015.
    9. Iwata H, Bieber K, Tiburzy B, Chrobok N, Kalies K, Shimizu A, Leineweber S, Ishiko A, Vorobyev A, Zillikens D, Köhl J, Westermann J, Seeger K, Manz R, Ludwig RJ:
      B cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita.
      J Immunol 191: 2978-2988, 2013.
    10. Iwata H, Kamio N, Aoyama Y, Yamamoto Y, Hirako Y, Owaribe K, Kitajima Y:
      IgG from patients with bullous pemphigoid depletes cultured keratinocytes of the 180-kDa bullous pemphigoid antigen (type XVII collagen) and weakens cell attachment.
      J Invest Dermatol 129: 919-926, 2009.

    Publication Lists (PubMed)

  • YANAGI Teruki
    Associate professor

    More

    Certification

    Board Certification by Japanese Dermatological Association

    Professional Societies

    The Japanese Dermatological Association
    The Japanese Society for Investigative Dermatology (Councilor)
    Japanese Cancer Association

    Education and professional experience

    2003 Mar M.D., Hokkaido University School of Medicine
    2003 May Resident, Dermatology Dept., Hokkaido Univ. Hospital
    2005 Apr Medical staff, Dermatology Dept., Tonan Hospital
    2006 Apr Resident, Dermatology Dept., Hokkaido Cancer Center
    2010 Mar Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
    2011 Apr JSPS Research Fellowship for Young Scientists
    2013 Apr JSPS Overseas Research Fellowship
    Sanford-Burnham Medical Research Institute (John C. Reed lab., USA)
    2015 Apr Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
    2016 Apr Specially appointed Assistant professor, Dermatology Dept., Faculty of Medicine and Graduate School of Medicine Hokkaido University
    2019 Apr Assistant professor, Dermatology Dept., Hokkaido Univ. Hospital
    2021 Apr Associate professor, Dermatology Dept., Hokkaido Univ. Hospital

    Major Publications

    1. Maeda T, Kitamura S, Nishihara H, Yanagi T:
      Extramammary Paget’s disease patient-derived xenografts harboring ERBB2 S310F mutation show sensitivity to HER2-targeted therapies.
      Oncogene 39: 5867-5875, 2020.
    2. Maeda T, Kitamura S, Yanagi T:
      RANK-RANKL signaling pathway contributes to disease progression in cutaneous angiosarcoma: A case report with an immunohistochemical review and in vitro experiments.
      J Eur Acad Dermatol Venereol 34: e834-e837, 2020.
    3. Yanagi T, Kitamura S, Imafuku K, Suto A, Maeda T, Tanaka S, Sesaki H, Abe R, Shimizu H:
      Loss of dynamin-related protein 1 (Drp1) does not affect epidermal development or UVB-induced apoptosis but does accelerate UVB-induced carcinogenesis.
      J Dermatol Sci 99: 109-118, 2020.
    4. Yanagi T, Watanabe M, Hata H, Kitamura S, Imafuku K, Yanagi H, Homma A, Wang L, Takahashi H, Shimizu H, Hatakeyama S:
      Loss of TRIM29 alters keratin distribution to promote cell invasion in squamous cell carcinoma.
      Cancer Res 78: 6795-6806, 2018.
    5. Yanagi T, Hata H, Mizuno E, Kitamura S, Imafuku K, Nakazato S, Wang L, Nishihara H, Tanaka S, Shimizu H:
      PCTAIRE1/CDK16/PCTK1 is overexpressed in cutaneous squamous cell carcinoma and regulates p27 stability and cell cycle.
      J Dermatol Sci 86: 149-157, 2017.
    6. Yanagi T, Tachikawa K, Wilkie-Grantham R, Hishiki A, Nagai K, Toyonaga E, Chivukula P, Matsuzawa SI:
      Lipid nanoparticle-mediated siRNA transfer Against PCTAIRE1/PCTK1/Cdk16 inhibits in vivo cancer growth.
      Mol Ther Nucleic Acids 5: e327, 2016.
    7. Yanagi T, Krajewska M, Matsuzawa S, Reed JC:
      PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells.
      Cancer Res 74; 5795-5807, 2014.
    8. Yanagi T, Akiyama M, Nishihara H, Ishikawa J, Sakai K, Miyamura Y, Naoe A, Kitahara T, Tanaka S, Shimizu H:
      Self-improvement of keratinocyte differentiation defects during skin maturation in ABCA12 deficient harlequin ichthyosis model mice.
      Am J Pathol 177: 106-118, 2010.
    9. Yanagi T, Akiyama M, Sakai K, Nagasaki A, Ozawa N, Kosaki R, Sago H, Shimizu H:
      DNA-based prenatal exclusion of harlequin ichthyosis.
      J Am Acad Dermatol 58: 653-656, 2008.
    10. Yanagi T, Akiyama M, Nishihara H, Sakai K, Nishie W, Tanaka S, Shimizu H.
      Harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal skin barrier defects.
      Hum Mol Genet 17: 3075-3083, 2008.

    Publication Lists (PubMed)

  • IZUMI Kentaro
    Assistant professor

    More

    Certification

    Board Certification by Japanese Dermatological Association

    Society

    The Japanese Dermatological Association
    The Japanese Society for Investigative Dermatology

    Education and professional experience

    2006 Mar M.D., Asahikawa Medical University School of Medicine
    2006 Apr Junior Resident, Sapporo Higashi Tokushukai Hospital
    2008 Apr Senior Resident, Dermatology Dept., Hokkaido Univ. Hospital
    2010 Apr Medical staff, Dermatology Dept., Kushiro City Hospital
    2011 Apr Medical staff, Dermatology Dept., Hakodate Central General Hospital
    2011 Jul Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
    2012 Mar Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
    2016 Oct Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
    2017 Oct Visiting scientist, University of Lübeck (Detlef Zillikens Lab., Germany)
    2020 Jan Assistant Professor, Dermatology Dept., Faculty of Medicine and Graduate School of Medicine Hokkaido University

    Major Publications

    1. Hayashi M, Tsunoda T, Sato F, Yaguchi Y, Igarashi M, Izumi K, Nishie W, Ishii N, Okamura K, Suzuki T, Hashimoto T:
      Clinical and immunological characterisation of 14 cases of dipeptidyl peptidase 4 inhibitor-associated bullous pemphigoid: a single centre study.
      Br J Dermatol 182: 806-807, 2020.
    2. Izumi K, Nishie W, Beniko M, Shimizu H:
      A Cross-Sectional Study Comparing the Prevalence of Bullous Pemphigoid Autoantibodies in 275 Cases of Type II Diabetes Mellitus Treated With or Without Dipeptidyl Peptidase-IV Inhibitors.
      Front Immunol 10: 1439, 2019.
    3. Izumi K, Bieber K, Ludwig RJ:
      Current Clinical Trials in Pemphigus and Pemphigoid.
      Front Immunol 10: 978, 2019.
    4. Tuusa J, Lindgren O, Tertsunen HM, Nishie W, Kokkonen N, Huilaja L, Izumi K, Herukka SK, Miettunen J, Shimizu H, Remes AM, Tasanen K:
      BP180 Autoantibodies Target Different Epitopes in Multiple Sclerosis or Alzheimer’s Disease than in Bullous Pemphigoid.
      J Invest Dermatol 139: 293-299, 2019.
    5. Mai Y, Nishie W, Sato K, Hotta M, Izumi K, Ito K, Hosokawa K, Shimizu H:
      Bullous Pemphigoid Triggered by Thermal Burn Under Medication With a Dipeptidyl Peptidase-IV Inhibitor: A Case Report and Review of the Literature.
      Front Immunol 9: 542, 2018.
    6. Izumi K , Nishie W, Mai Y, Ujiie H, Iwata H, Natsuga K, Shimizu H:
      Detection of mucous membrane pemphigoid autoantibodies by full-length BP180 enzyme-linked immunosorbent assay.
      J Dermatol Sci 88: 247-248, 2017.
    7. Toyonaga E, Nishie W, Izumi K, Natsuga K, Ujiie H, Iwata H, Yamagami J, Hirako Y, Sawamura D, Fujimoto W, Shimizu H:
      C-Terminal Processing of Collagen XVII Induces Neoepitopes for Linear IgA Dermatosis Autoantibodies.
      J Invest Dermatol 137: 2552-2559, 2017.
    8. Izumi K, Nishie W, Mai Y, Wada M, Natsuga K, Ujiie H, Iwata H, Yamagami J, Shimizu H:
      Autoantibody profile differentiates between inflammatory and non-inflammatory bullous pemphigoid.
      J Invest Dermatol 136: 2201-2210, 2016.
    9. Wada M, Nishie W, Ujiie H, Izumi K, Iwata H, Natsuga K, Nakamura H, Kitagawa Y, Shimizu H:
      Epitope-dependent pathogenicity of Abs targeting a major bullous pemphigoid autoAg collagen XVII/BP180.
      J Invest Dermatol 136: 938-946, 2016.
    10. Nishie W, Natsuga K, Iwata H, Izumi K, Ujiie H, Toyonaga E, Hata H, Nakamura H, Shimizu H:
      Context-Dependent Regulation of Collagen XVII Ectodomain Shedding in Skin.
      Am J Pathol 185: 1361-1371, 2015.

    Publication Lists (PubMed)

  • KITAMURA Shinya
    Assistant professor

    More

    Certification

    Board Certification by Japanese Dermatological Association

    Professional Societies

    The Japanese Dermatological Association
    Japanese Skin Cancer Society
    Japan Organization of Clinical Dermatologists

    Education and professional experience

    2011 Mar M.D., Saga University School of Medicine
    2011 Apr Junior Resident, Chitose City Hospital
    2013 Apr Senior Resident, Dermatology Dept., Hokkaido Univ. Hospital
    2013 Dec Medical staff, Dermatology Dept., Obihiro Kosei Hospital
    2014 Apr Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
    2020 Mar  Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
    2021 Apr  Assistant professor, Dermatology Dept., Hokkaido Univ. Hospital

    Major Publications

    1. Maeda T#, Kitamura S#, Nishihara H, Yanagi T:
      Extramammary Paget’s disease patient-derived xenografts harboring ERBB2 S310F mutation show sensitivity to HER2-targeted therapies.
      Oncogene 39; 5867-5875, 2020. # co-first author
    2. Kitamura S, Maeda T, Yanagi T:
      Vandetanib inhibits cell growth in EGFR-expressing cutaneous squamous cell carcinoma.
      Biochem Biophys Res Commun 531: 396-401, 2020.
    3. Kitamura S, Yanagi T, Maeda T, Shimizu H:
      Drp1 expression levels correlate with clinical stage in extramammary Paget’s disease.
      J Eur Acad Dermatol Venereol 34: e510-e513, 2020.
    4. Kitamura S, Yanagi T, Inamura-Takashima Y, Imafuku K, Hata H, Fujioka Y, Ohba Y, Shimizu H:
      Dermoscopic evaluation for skin grafts after surgery; neo-vascularization correlates with survival of skin grafts: a prospective study.
      J Dermatol Sci 90; 213-216, 2018.
    5. Kitamura S, Yanagi T, Imafuku K, Hata H, Shimizu H:
      Lipofuscin deposition causes the pigmentation of apocrine hidrocystoma.
      J Dermatol 45; 91-94, 2018.
    6. Kitamura S, Yanagi T, Inamura-Takashima Y, Imafuku K, Hata H, Uehara J, Ishida Y, Otsuka A, Hirata K, and Shimizu H:
      Retrospective study on the correlation between 18-fluorodeoxyglucose uptake in positron emission tomography-computer tomography and tumor volume, cytological activity as assessed with Ki-67 and GLUT-1 staining in 10 cases of Merkel cell carcinoma.
      J Eur Acad Dermatol Venereol 32, e285-e287, 2018.
    7. Kitamura S, Yanagi T, Imafuku K, Hata H, Abe R, Shimizu H:
      Drp1 regulates mitochondrial morphology and cell proliferation in cutaneous squamous cell carcinoma.
      J Dermatol Sci 88: 298-307, 2017.
    8. Kitamura S, Yanagi T, Inamura Y, Hata H, Imafuku K, Yoshino K, Shimizu H:
      Pazopanib does not bring remarkable improvement in patients with angiosarcoma.
      J Dermatol 44: 64-67, 2017.
    9. Kitamura S, Hata H, Imafuku K, Fujita Y, Shimizu H:
      Dermoscopic findings of irritated seborrheic keratosis.
      J Eur Acad Dermatol Venereol 30: e94-e96, 2016.
    10. Kitamura S, Hata H, Inamura Y, Imafuku K, Sakashita T, Hirata K, Shimizu H:
      Positron emission tomography-computed tomography can be useful in the early detection of metastases in primary mucinous carcinoma of the skin on the head and neck.
      Br J Dermatol 173: 1263-1265, 2015.

    Publication Lists (PubMed)

  • MIYAUCHI Toshinari
    Assistant professor

    More

    Certification

    Board Certification by Japanese Dermatological Association

    Professional Societies

    The Japanese dermatological association
    The Japanese Society for Investigative Dermatology
    Japan Organization of Clinical Dermatologists
    European Society for Dermatological Research
    The Japan Society of Human Genetics

    Education and professional experience

    2011 Mar M.D., Hokkaido University School of Medicine
    2011 Apr Junior Resident, Ebetsu City Hospital
    2012 Apr Junior Resident, Hokkaido Univ. Hospital
    2013 Apr Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
    2013 May Medical staff, Dermatology Dept., Kushiro City Hospital
    2013 Sep Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
    2014 Apr Senior Resident, Dermatology Dept., Sapporo City Hospital
    2015 Apr Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
    2019 Apr Medical staff, Dermatology Dept., Chitose City Hospital
    2020 Apr Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
    2021 Mar Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
    2021 Apr Assistant professor, Dermatology Dept., Hokkaido Univ. Hospital

    Major Publications

    1. Miyauchi T, Suzuki S, Takeda M, Peh JT, Aiba M, Natsuga K, Fujita Y, Takeichi T, Sakamoto T, Akiyama M, Shimizu H, Nomura T:
      Altered replication stress response due to CARD14 mutations promotes recombination-induced revertant mosaicism.
      Am J Hum Genet 108: 1026-1039, 2021.
    2. Suzuki S, Nomura T, Miyauchi T, Takeda M, Fujita Y, Nishie W, Akiyama M, Ishida-Yamamoto A, Shimizu H:
      Somatic recombination underlies frequent revertant mosaicism in loricrin keratoderma.
      Life Sci Alliance 2: e201800284, 2019.
    3. Katayama S, Nomura T, Takeda M, Miyauchi T, Suzuki S, Peh JT, Nohara T, Kitamura S, Hata H, Shimizu H:
      A Case of Malignant Melanoma Arising in Nagashima-type Palmoplantar Keratosis.
      Acta Derm Venereol 99: 1311-1312, 2019.
    4. Nomura T, Suzuki S, Miyauchi T, Takeda M, Shinkuma S, Fujita Y, Nishie W, Akiyama M, Shimizu H:
      Chromosomal inversions as a hidden disease-modifying factor for somatic recombination phenotypes.
      JCI Insight 3: e97595, 2018.
    5. Ohguchi Y, Nomura T, Suzuki S, Takeda M, Miyauchi T, Mizuno O, Shinkuma S, Fujita Y, Nemoto O, Ono K, McLean WHI, Shimizu H:
      Gentamicin-induced readthrough and nonsense-mediated mRNA decay of SERPINB7 nonsense mutant transcripts.
      J Invest Dermatol 138: 836-843, 2018.
    6. Kosumi H, Miyauchi T, Nomura T, Suzuki S, Ohguchi Y, Nomura A, Shimizu H:
      Diagnostic features of acquired dermal melanocytosis of the face and extremities: A case report and review of the literature.
      Clin Exp Dermatol 43: 806-809, 2018.
    7. Takeda M, Nomura T, Sugiyama T, Miyauchi T, Suzuki S, Fujita Y, Shimizu H:
      Compound heterozygous missense mutations p.Leu207Pro and p.Tyr544Cys in TGM1 cause a severe form of lamellar ichthyosis.
      J Dermatol 45: 1463-1467, 2018.
    8. Suzuki S, Nomura T, Miyauchi T, Takeda M, Nakamura H, Shinkuma S, Fujita Y, Akiyama M, Shimizu H:
      Revertant mosaicism in ichthyosis with confetti caused by a novel frameshift mutation in KRT1.
      J Invest Dermatol 136: 2093-2095, 2016.
    9. Miyauchi T, Nomura T, Suzuki S, Ohguchi Y, Yamaguchi Y, Shinkuma S, Natsuga K, Fujita Y, Shimizu H:
      Extensive erythema and hyperkeratosis on the extremities and lumbar area as an unusual manifestation of Nagashima-type palmoplantar keratosis.
      Acta Derm Venereol 96: 856-858, 2016.
    10. Miyauchi T, Nomura T, Suzuki S, Takeda M, Shinkuma S, Arita K, Fujita Y, Shimizu H:
      Genetic analysis of a novel splice-site mutation in TMC8 reveals the in-vivo importance of the TMC domain of TMC8.
      Br J Dermatol 175: 803-806, 2016.

    Publication Lists (PubMed)

Medical Staffs / Residents / Visiting Clinical Doctors
  • KENMOTSU Yasuko
  • UJIIE Inkin
  • TSUJIWAKI Masumi
  • MIYAZAWA Hajime
  • SEO Takashi
  • OGAWA Hiroki
  • HIRANO Yoko
  • TANAKA Arisa
  • HASE Takahiro
  • KIMURA Ayame
  • YOUH Joohyung
  • YAMAGA Misako
Ph.D. Course Students
  • YOSHIMOTO Norihiro
  • IMAFUKU Keisuke
  • MAI Yosuke
  • KOSUMI Hideyuki
  • PEH Jin Teng
  • MAI Shoko
  • MAEDA Takuya
  • TOKUCHI Keiko
  • TAKEDA Masae
  • WENG Yu
  • SHIIYA Chihiro
  • NOHARA Takuma
  • WATANABE Haruhisa
  • HSU Che-yuan
Researchers
  • ZHENG Miao
  • WANG Yunan
Central Research Institute
  • NAKAMURA Hideki
Researching Abroad
  • WATANABE Mika
  • ITO Takamasa
  • TAKASHIMA Shota
  • MURAMATSU Ken
Laboratory Technicians
  • IKESHITA Nami
  • TANABE Mika
  • TAKEHARA Megumi
  • YAMASHITA Miho
Medical Secretaries
  • FRANK Mayumi
Secretaries
  • OGAWA Satomi
  • KASAI Kanako
  • OSUMI Maki
On leave of absence
  • TOYONAGA Ellen
  • TAKASHIMA Yuka
Professor Emeritus
  • OHKAWARA Akira
Visiting Professors
  • NISHIE Wataru
  • NOMURA Toshifumi
Assistant Adjunct Professors
  • KUMAKIRI Masanobu
  • SATO Hidetsugu
  • MATSUMURA Kazuko
  • SHIMIZU Satoko
  • KODAMA Kazuo
  • NAKAMURA Hiroyuki
  • ITO Kei
  • OTA Mitsuhito
  • HOSHINA Daichi
  • ANAN Takashi
  • MIZUNO Osamu
  • SUZUKI Shotaro
  • FUJITA Yasuyuki
  • FUJIMURA Yu
  • HOTTA Moeko