Faculty

• UJIIE Hideyuki

  Professor and Chair

  Fields of specialty

  Autoimmune blistering diseases, Atopic dermatitis, Skin immunology

  More

  Certification

  Board Certification by Japanese Dermatological Association

  Professional Societies

  The Japanese Dermatological Association (Delegate and Guideline Committee Member)
  The Japanese Society for Investigative Dermatology (Councilor)
  Japan Organization of Clinical Dermatologists
  Japanese Society for Immunology
  Japanese Society of Allergology (Hokkaido Branch Councilor)
  The Japanese Society for Cutaneous Immunology and Allergy (Delegate and Guideline Committee Member)
  Japanese Society for Psoriasis Research (Councilor)
  Society for Investigative Dermatology
  European Society for Dermatological Research

  Education and professional experience

  2002 Mar M.D., Hokkaido University School of Medicine
  2002 May Resident, Dermatology Dept., Hokkaido Univ. Hospital
  2005 Apr Resident, Dermatology Dept., Hokkaido Cancer Center
  2010 Mar Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2010 Apr Assistant professor, Dermatology Dept., Hokkaido Univ. Hospital
  2012 Sep Visiting fellow, National Institutes of Health (NIH) (Ethan Shevach Lab., USA)
  2013 Apr JSPS Overseas Research Fellowship
  2014 Sep Assistant professor, Dermatology Dept., Hokkaido Univ. Hospital
  2016 Sep Associate professor, Dermatology Dept., Hokkaido Univ. Hospital
  2021 Jan Professor and chairman, Dermatology Dept., Faculty of Medicine and Graduate School of Medicine Hokkaido University

  Major Publications

  1. Muramatsu K, Zheng M, Yoshimoto N, Ito T, Ujiie I, Iwata H, Shimizu H, Ujiie H:
     Regulatory T cell subsets in bullous pemphigoid and dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid.
     J Dermatol Sci 100: 23-30, 2020.
  2. Ujiie H, Iwata H, Yamagami J, Nakama T, Aoyama Y, Ikeda S, Ishii N, Iwatsuki K, Kurosawa M, Sawamura D, Tanikawa A, Tsuruta D, Nishie W, Fujimoto W, Amagai M, Shimizu H, Committee for Guidelines for the Management of Pemphigoid Diseases (Including Epidermolysis Bullosa Acquisita):
     Japanese guidelines for the management of pemphigoid (including epidermolysis bullosa acquisita).
     J Dermatol 46: 1102-1135, 2019.
  3. Ujiie H, Yoshimoto N, Natsuga K, Muramatsu K, Iwata H, Nishie W, Shimizu H:
     Immune reaction to type XVII collagen induces intramolecular and intermolecular epitope spreading in experimental bullous pemphigoid models.
     Front Immunol 10: 1410, 2019.
  4. Ujiie I, Ujiie H, Iwata H, Shimizu H:
     Clinical and immunological features of pemphigus relapse.
     Br J Dermatol 180: 1498-1505, 2019.
  5. Muramatsu K, Ujiie H, Kobayashi I, Nishie W, Izumi K, Ito T, Yoshimoto N, Natsuga K, Iwata H, Shimizu H:
     Regulatory T-cell dysfunction induces autoantibodies to bullous pemphigoid antigens in mice and human subjects.
     J Allergy Clin Immunol 142: 1818-1830, 2018.
  6. Ujiie H, Muramatsu K, Mushiroda T, Ozeki T, Miyoshi H, Iwata H, Nakamura A, Nomoto H, Cho KY, Sato N, Nishimura M, Ito T, Izumi K, Nishie W, Shimizu H:
     HLA-DQB1*03:01 as a biomarker for genetic susceptibility to bullous pemphigoid induced by DPP-4 inhibitors.
     J Invest Dermatol 138: 1201-1204, 2018.
  7. Sasaoka T^#, Ujiie H^#, Nishie W, Iwata H, Ishikawa M, Higashino H, Natsuga K, Shinkuma S, Shimizu H:
     Intravenous IgG reduces pathogenic autoantibodies, serum IL-6 levels, and disease severity in experimental bullous pemphigoid models.
     J Invest Dermatol 138: 1260-1267, 2018. ^# co-first author
  8. Ujiie H, Shevach EM:
     gdT cells protect liver and lung of mice from the autoimmunity induced by scurfy lymphocytes.
     J Immunol 196: 1517-1528, 2016.
  9. Ujiie H, Sasaoka T, Izumi K, Nishie W, Shinkuma S, Natsuga K, Nakamura H, Shibaki A, Shimizu H:
     Bullous pemphigoid autoantibodies directly induce blister formation without complement activation.
     J Immunol 193: 4415-4428, 2014.
  10. Ujiie H, Shibaki A, Nishie W, Sawamura D, Wang G, Tateishi Y, Li Q, Moriuchi R, Qiao H, Nakamura H, Akiyama M, Shimizu H:
      A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen.
      J Immunol 184: 2166-2174, 2010.

  Publication Lists (PubMed)

• NATSUGA Ken

  Senior Associate Professor

  Fields of specialty

  Epidermolysis bullosa, Psoriasis, Epidermal stem cells

  More

  Certification

  Ph.D., Hokkaido University Graduate School of Medicine, Japan (2010)
  Board Certification by Japanese Dermatological Association (2008)
  M.D., Hokkaido University School of Medicine, Japan (2003)

  Professional Societies

  The Japanese Dermatological Association
  The Japanese Society for Investigative Dermatology (2020-2023 Junior Board Director, 2022-Diversity Committee Member)
  Japan Organization of Clinical Dermatologists
  European Society for Dermatological Research
  Society for Investigative Dermatology
  Japan Skin Research Club (Organizer)
  The Japan Society of Human Genetics
  Japanese Society of Vitiligo
  Japanese Society for Psoriasis Research

  Education and professional experience

  2003 Mar M.D., Hokkaido University School of Medicine
  2003 Mar Resident, Dermatology Dept., Hokkaido Univ. Hospital
  2005 Apr Resident, Dermatology Dept., Hokkaido Cancer Center
  2006 Apr Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2010 Mar Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2010 Sep Visiting Scientist, Cancer Research UK Cambridge Research Institute (Fiona Watt Lab., UK)
  2011 Apr JSPS Overseas Research Fellowship
  2012 Sep Assistant professor, Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2016 Aug Associate professor, Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2021 Feb Senior associate professor, Dermatology Dept., Faculty of Medicine and Graduate School of Medicine Hokkaido University
  2021 Apr Senior associate professor, Research Institute for Electronic Science, Hokkaido University

  Major Publications

  1. Mai Y, Kobayashi Y, Kitahata H, Seo T, Nohara T, Itamoto S, Mai S, Kumamoto J, Nagayama M, Nishie W, Ujiie H, Natsuga K:
     Patterning in stratified epithelia depends on cell-cell adhesion.
     Life Sci Alliance 7: e202402893, 2024.
  2. Natsuga K, Furuta Y, Takashima S, Nohara S, Kosumi H, Mai Y, Higashi H, Ujiie H:
     Detection of revertant mosaicism in epidermolysis bullosa through Cas9-targeted long read sequencing.
     Hum Mutat 43: 529-536, 2022.
  3. Wang Y, Kitahata H, Kosumi H, Watanabe M, Fujimura Y, Takashima S, Osada SI, Hirose T, Nishie W, Nagayama M, Shimizu H, Natsuga K:
     Collagen XVII deficiency alters epidermal patterning.
     Lab Invest 102: 581-588, 2022.
  4. Kosumi H, Watanabe M, Shinkuma S, Fujimura Y, Tsukiyama T, Donati G, Iwata H, Ujiie H, Natsuga K:
     Wnt/beta-catenin signaling stabilizes hemidesmosomes in keratinocytes.
     J Invest Dermatol 142: 1576-1586, 2022.
  5. Fujimura Y, Watanabe M, Ohno K, Kobayashi Y, Takashima S, Nakamura H, Kosumi H, Wang Y, Mai Y, Lauria A, Proserpio V, Ujiie H, Iwata H, Nishie W, Nagayama M, Oliviero S, Donati G, Shimizu H, Natsuga K:
     Hair follicle stem cell progeny heal blisters while pausing skin development.
     EMBO Rep 22: e50882, 2021.
  6. Watanabe M, Natsuga K, Nishie W, Kobayashi Y, Donati G, Suzuki S, Fujimura Y, Ujiie H, Shinkuma S, Nakamura H, Murakami M, Ozaki M, Nagayama M, Watt FM, Shimizu H:
     Type XVII collagen coordinates proliferation in the interfollicular epidermis.
     Elife 6: e26635, 2017.
  7. Natsuga K, Cipolat S, Watt FM:
     Increased bacterial load and expression of antimicrobial peptides in skin of barrier-deficient mice with reduced cancer susceptibility.
     J Invest Dermatol 136: 99-106, 2016.
  8. Natsuga K, Nishie W, Shinkuma S, Ujiie H, Nishimura M, Sawamura D, Shimizu H:
     Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and -independent manner.
     J Immunol 188: 5792-5799, 2012.
  9. Natsuga K, Nishie W, Smith BJ, Shinkuma S, Smith TA, Parry DA, Oiso N, Kawada A, Yoneda K, Akiyama M, Shimizu H:
     Consequences of two different amino-acid substitutions at the same codon in KRT14 endicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis.
     J Invest Dermatol 131: 1869-1876, 2011.
  10. Natsuga K, Nishie W, Akiyama M, Nakamura H, Shinkuma S, McMillan JR, Nagasaki A, Has C, Ouchi T, Ishiko A, Hirako Y, Owaribe K, Sawamura D, Bruckner-Tuderman L, Shimizu H:
      Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex.
      Hum Mutat 31: 308-316, 2010.

  Publication Lists (PubMed)

• WATANABE Mika

  Associate professor

  Fields of specialty

  Wound healing, Epidermal stem cells, Epidermolysis bullosa

  More

  Certification

  Board Certification by Japanese Dermatological Association

  Professional Societies

  The Japanese Dermatological Association
  The Japanese Society for Investigative Dermatology (Guideline Committee Member)
  Japanese Society for Psoriasis Research
  Japan Organization of Clinical Dermatologists
  European Society for Dermatological Research

  Education and professional experience

  2007 Mar　M.D.,Hokkaido University School of Medicine
  2007 Apr　Resident, Tokyo Metropolitan Bokutoh Hospital
  2009 Apr　Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2011Apr　Senior Resident, Dermatology Dept., Sapporo City General Hospital
  2012 Apr　Medical staff, Dermatology Dept., JR Sapporo Hospital
  2013 Apr　Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2017 Dec　Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2018 Apr　Postdoctral researcher, University of Turin, Molecular biotechnology center (Giacomo Donati Lab, Italy)
  2019 Apr    JSPS Overseas Research Fellowship
  2023 Jan   Assistant Professor, Dermatology Dept., Hokkaido Univ. Hospital
  2024 Jan   Associate Professor, Dermatology Dept., Hokkaido Univ. Hospital

  Major Publications

  1. Levra levron C†, Watanabe M†, Proserpio V† (†: co-first authors), Piacenti G, Lauria A, Kaltenbach S, Tamburrini A, Nohara T, Anselmi F, Duval C, Elettrico L, Donna D, Conti L, Baev D, Natsuga K, Hagai T, Oliviero S, Donati G:
     Tissue memory relies on stem cell priming in distal undamaged areas.
     Nat Cell Biol, 25: 740–753, 2023.
  2. Kosumi H, Watanabe M, Shinkuma S, Nohara T, Fujimura Y, Tsukiyama T, Donati G, Iwata H, Nakamura H, Ujiie H, Natsuga K:
     Wnt/β-catenin signaling stabilizes hemidesmosomes in keratinocytes.
     J Invest Dermatol, 142: 1576-158, 2022.
  3. Wang Y, Kitahata H, Kosumi H, Watanabe M, Fujimura Y, Takashima S, Osada S-I, Hirose T, Nishie W, Nagayama M, Shimizu H, Natsuga K:
     Collagen XVII deficiency alters epidermal patterning.
     Lab Invest, 102: 581–588, 2022.
  4. Watanabe M, Kosumi H, Osada S-I, Takashima S, Wang Y, Nishie W, Oikawa T, Hirose T, Shimizu H, Natsuga K:
     Type XVII collagen interacts with the aPKC‐PAR complex and maintains epidermal cell polarity.
     Exp Dermatol, 30: 62–67,2021.
  5. Fujimura Y, Watanabe M, Ohno K, Kobayashi Y, Takashima S, Nakamura H, Kosumi H, Wang Y, Mai Y, Lauria A, Proserpio V, Ujiie H, Iwata H, Nishie W, Nagayama M, Oliviero S, Donati G, Shimizu H, Natsuga K:
     Hair follicle stem cell progeny heal blisters while pausing skin development.
     EMBO Rep, 22: e50882, 2021.
  6. Watanabe M, Natsuga K, Shinkuma S, Shimizu H:
     Epidermal aspects of type VII collagen: implications for dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita.
     J Dermatol, 45: 515-521, 2018.
  7. Kosumi H, Watanabe M, Natsuga K, Miyauchi T, Shiiya C, Ujiie H, Shimizu H:
     Sweet’s syndrome mimicking ANCA-associated vasculitis.
     Am J Med, 131: e241-e242, 2018.
  8. Watanabe M, Natsuga K, Nishie W, Kobayashi Y, Donati G, Suzuki S, Fujimura Y, Ujiie H, Shinkuma S, Nakamura H, Murakami M, Ozaki M, Nagayama M, Watt FM, Shimizu H:
     Type XVII collagen coordinates proliferation in the interfollicular epidermis.
     ELife, 6: e26635, 2017.
  9. Hayashi R, Natsuga K, Watanabe M, Iwata H, Shinkuma S, Ito A, Masui Y, Ito M, Shimomura Y:
     Epidermolysis bullosa acquisita develops in dominant dystrophic epidermolysis bullosa.
     J Invest Dermatol, 136:320-3, 2016.
  10. Watanabe M, Ujiie H, Nishimura K, Kamiyama T, Abe R, Shimizu H:
      Mycosis fungoides associated with splenic infarction and muscle involvement.
      Br J Dermatol, 173; 1100-1102, 2015.

  Publication Lists (PubMed)

• ITO Takamasa

  Assistant professor

  Fields of specialty

  Immunology

  More

  Certification

  Board Certification by Japanese Dermatological Association

  Professional Societies

  The Japanese Dermatological Association
  The Japanese Society for Investigative Dermatology
  Japan Organization of Clinical Dermatologists

  Education and professional experience

  2010　M.D.,Hokkaido University School of Medicine
  2010　Resident, Chigasaki Tokushukai General Hospital
  2012　Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2013　Senior Resident, Dermatology Dept., Sapporo City General Hospital
  2015　Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2018　Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2019　Department director, Dermatology Dept., Tonan hospital
  2020　Postdoctral fellow, Columbia University, The department of  microbiology and immunology (Huang Yuefeng Lab, USA)
  2022    JSPS Overseas Research Fellowship
  2024　Assistant Professor, Dermatology Dept., Hokkaido Univ. Hospital

  Major Publications

  1. Ito T, Wu C, Zhang Y, Ishida Y, Guichard V, Zhang W, Huang L, Han R, Guckian K, Chun J, Que J, Smith A, Urban JF Jr and Huang Y^,
     
     Inflammatory ILC2s migrate to distal tissues during infection using stage-specific S1P receptors
     Sci Immunol. In press
  2. Ito T*, Kimura A, Ken Muramatsu, Kawamura T, Katayama S, Siiya C, Natsuga K, Iwata H, UjiieH*:
     Eosinophil derived neurotoxin and eosinophil cationic protein are key molecules for blister formation in pemphigoid (*corresponding author)
     J Allergy Clin Immunol. 156(3):705-718: 2025
  3. Guichard V, Leão FB, Zhao J, Zhang Y, Ito T, Shirley S, Postler TS, Tian R, Huang Y, Ghosh S:
     Prexisting epigenetic state and differential NF-kB activation shapes type 2 immune cell response.
     Immunity; 10;58(6):1422-1437.e6: 2025
  4. Dorrity TJ, Shin H, Wiegand KA, Aruda J, Closser M, Jung E, Gertie JA, Leone A, Polfer R, Culbertson B, Yu L, Wu C, Ito T, Huang Y, Steckelberg AL, Wichterle H, Chung H:
     Long 3’UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation.
     Sci Immunol. 8: eadg2979, 2023.
  5. Zhang Y, Zhang W, Zhao J, Ito T, Jin J, Aparicio AO, Zhou J, Guichard V, Fang Y, Que J, Urban JF Jr, Hanna JH, Ghosh S, Wu X, Ding L, Basu U, Huang Y
     m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner.
     Nat Immunol. 24:1256-1264, 2023.
  6. Ito T, Ujiie H:
     Serpiginous erythema on the trunk.
     BMJ. 372: m4967, 2021(*corresponding author).
  7. Ito T, Shiromizu T, Ohnishi S, Suzuki S, Mabe K, Hasegawa A, Ujiie H, Fujita Y, Kato M, Asaka M, Tomonaga T, Shimizu H, Abe R:
     Potentail role of extracellular vesicle-mediated antigen presentation in Helicobacter pylori hypersensitivity during eradication therapy.
     J Allergy Clin Immunol. 142; 672-6, 2018.
  8. Ito T, Nomura T, Fujita Y, Abe R, Shimizu H:
     Tubular apocrine adenoma clinically and dermoscopically mimicking basal cell carcinoma.
     J Am Acad Dermatol. 71: e45-6,
  9. Ito T, Fujita Y, Nomura T, Abe R, Shimizu H:
     Dermoscopy of Pseudoxanthoma Elasticum-like Papillary Dermal Elastolysis.
     J Am Acad Dermatol. 69: 202-3, 2013.
  10. Ito T, Nishie W, Fujita Y, Abe R, Shimizu H:
      Infantile eczema caused by formula milk.
      Lancet. 381: 1958, 2013. 

  Publication Lists (PubMed)

• MURAMATSU Ken

  Assistant professor

  Fields of specialty

  Autoimmune blistering diseases, Skin immunology

  More

  Certification

  Board Certification by Japanese Dermatological Association
  Board Certification by Japanese Association for Medical Artificial Intelligence

  Professional Societies

  The Japanese Dermatological Association
  The Japanese Society for Investigative Dermatology
  The Japanese Association for Medical Artificial Intelligence

  Education and professional experience

  2011 Mar　M.D.,Hokkaido University School of Medicine
  2011 Apr　Junior Resident, Hokkaido Univ. Hospital
  2012 Apr　Junior Resident, Obihiro Kosei Hospital
  2013 Apr　Senior Resident, Dermatology Dept., Hokkaido Univ. Hospital
  2014 Apr　Senior Resident, Dermatology Dept., KKR Sapporo Medical Center
  2019 Mar　Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2019 Apr　Medical Staff, Dermatology Dept., JR Sapporo Hospital
  2020 Apr　Medical Staff, Dermatology Dept., Kushiro City General Hospital
  2020 Jul　Medical Staff, Dermatology Dept., Hokkaido Univ. Hospital
  2021 Oct Research Fellow, Agency for Science, Technology and Research（Florent GINHOUX Lab, Singapore）
  2022 Oct JSPS Overseas Research Fellowship (Agency for Science, Technology and Research)
  2023 Nov Assistant Professor, Dermatology Dept., Hokkaido Univ. Hospital

  Major Publications

  1. Kawamura T, Muramatsu K, Orita A, Mai Y, Sugai T, Haga N, Fujimura Y, Miyauchi T, Izumi K, Koga H, Ishii N, Ujiie H:
     Two cases of Hallopeau-type pemphigus vegetans with anti-desmoglein 1 and anti-desmocollin 3 antibodies without mucosal involvement.
     J Eur Acad Dermatol Venereol 37: e508-e510, 2023.
  2. Ozeki T, Muramatsu K, Yoshimoto N, Ujiie I, Izumi K, Iwata H, Mushiroda T, Ujiie H:
     Association of Genetic Variants of HLA-DQA1 with Bullous Pemphigoid Induced by Dipeptidyl Peptidase-4 Inhibitors.
     J Invest Dermatol 143: 2219-2225.e5, 2023.
  3. Muramatsu K, Zheng M, Yoshimoto N, Ito T, Ujiie I, Iwata H, Shimizu H, Ujiie H:
     Regulatory T cell subsets in bullous pemphigoid and dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid.
     J Dermatol Sci 100: 23-30, 2020.
  4. Muramatsu K, Ujiie H, Kobayashi I, Nishie W, Izumi K, Ito T, Yoshimoto N, Natsuga K, Iwata H, Shimizu H:
     Regulatory T-cell dysfunction induces autoantibodies to bullous pemphigoid antigens in mice and human subjects.
     J Allergy Clin Immunol 142: 1818-1830.e6, 2018.
  5. Ujiie H, Muramatsu K, Mushiroda T, Ozeki T, Miyoshi H, Iwata H, Nakamura A, Nomoto H, Cho KY, Sato N, Nishimura M, Ito T, Izumi K, Nishie W and Shimizu H:
     HLA-DQB1*03:01 as a biomarker for susceptibility to bullous pemphigoid induced by DPP-4 inhibitor.
     J Invest Dermatol 138: 1201-1204, 2018.
  6. Muramatsu K, Ujiie H, Shimizu H:
     Postherpetic abdominal pseudohernia.
     BMJ 358: j2786, 2017.
  7. Muramatsu K, Ujiie H, Natsuga K, Nishie W, Shimizu H:
     Lichenoid drug eruption caused by clonazepam.
     J Eur Acad Dermatol Venereol 31: e117-e118, 2017.
  8. Muramatsu K, Nishie W, Natsuga K, Fujita Y, Iwata H, Yamada T, Yamashita E, Asaka T, Shimizu H:
     Two cases of erosive oral lichen planus with autoantibodies to desmoglein 3.
     J Dermatol 43: 1350-1353, 2016.
  9. Muramatsu K, Fujita Y, Inokuma D, Tsukinaga I, Ito K, Nishiura Y, Shimizu H:
     Cutaneous Manifestations of Thymoma-associated Multi-organ Autoimmunity: A Fatal Sign.
     Acta Dermato-Venereol 96: 818-819, 2016.
  10. Muramatsu K, Nomura T, Ito T, Hamade Y, Hirata Y, Fujita Y, Abe R, Shimizu H:
      Repeated skin sampling and prolonged incubation period identified cutaneous Mycobacaterium chelonae infection on the face in an immunocompetent man.
      Br J Dermatol 170: 471-473, 2014.

  Publication Lists (PubMed)

• MIYAUCHI Toshinari

  Assistant professor

  Fields of specialty

  Genetic skin diseases, Cell cycle

  More

  Certification

  Board Certification by Japanese Dermatological Association

  Professional Societies

  The Japanese dermatological association
  The Japanese Society for Investigative Dermatology
  Japan Organization of Clinical Dermatologists
  European Society for Dermatological Research
  The Japan Society of Human Genetics

  Education and professional experience

  2011 Mar  M.D., Hokkaido University School of Medicine
  2011 Apr  Junior Resident, Ebetsu City Hospital
  2012 Apr  Junior Resident, Hokkaido Univ. Hospital
  2013 Apr  Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2013 May  Medical staff, Dermatology Dept., Kushiro City Hospital
  2013 Sep  Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2014 Apr  Senior Resident, Dermatology Dept., Sapporo City Hospital
  2015 Apr  Medical staff, Dermatology Dept., Hokkaido Univ. Hospitalor Resident, Ebetsu City Hospita
  l2019 Apr  Medical staff, Dermatology Dept., Chitose City Hospital
  2020 Apr  Medical staff, Dermatology Dept., Hokkaido Univ. Hospital
  2021 Mar  Ph.D., Dermatology Dept., Graduate School of Medicine, Hokkaido University
  2021 Apr  Assistant professor, Dermatology Dept., Hokkaido Univ. Hospital
  2022 Jun  Postdoctoral Fellow, The Francis Crick Institute, Chromosome Replication Laboratory (John Diffley Lab., UK)
  2025 Oct  Assistant professor, Dermatology Dept., Hokkaido Univ. Hospital

  Major Publications

  1. Ansai O, Miyauchi T (co-first), Hayashi R, Katsumi T, Nishiguchi T, Hasegawa A, Shinkuma S, Natsuga K, Nomura T, Shimomura Y, Abe R:
     Interleukin-18 as a severity marker and novel potential therapeutic target for epidermolytic ichthyosis.
     Clin Exp Dermatol 48: 199-210, 2023.
  2. Yamaga M, Miyauchi T, JT Peh, Itamoto S, Mai Y, Iwata H, Nomura T, Ujiie H:
     Case report: Difference in outcomes between two cases of Hailey-Hailey disease treated with apremilast.
     Front Genet 13: 884359, 2022.
  3. Kimura A, Miyauchi T, Peh JT, Yanagi T, Hasegawa S, Morita S, Ujiie H:
     Palmoplantar keratoderma with deafness due to GJB2 mutation can develop ichthyosiform symptoms: a case report.
     J Eur Acad Dermatol Venereol 36: e693-e695, 2022.
  4. akimoto-Sato M, Miyauchi T (co-first), Suzuki M, Ujiie H, Nomura T, Ikari T, Nakamura T, Takahashi K, Matsumoto-Sasaki M, Kimura H, Kimura H, Matsui Y, Kitagataya T, Yamada R, Suzuki K, Nakamura A, Nakai M, Sho T, Ogawa K, Sakamoto N, Yamaguchi N, Otsuka N, Tomaru U, Konno S:
     Case Report: Hereditary Fibrosing Poikiloderma With Tendon Contractures, Myopathy, and Pulmonary Fibrosis (POIKTMP) Presenting With Liver Cirrhosis and Steroid-Responsive Interstitial Pneumonia.
     Front Genet 13: 870192, 2022.
     
  5. Miyauchi T, Suzuki S, Takeda M, Peh JT, Aiba M, Natsuga K, Fujita Y, Takeichi T, Sakamoto T, Akiyama M, Shimizu H, Nomura T:
     Altered replication stress response due to CARD14 mutations promotes recombination-induced revertant mosaicism. 
     Am J Hum Genet 108: 1026-1039, 2021.
  6. Suzuki S, Nomura T, Miyauchi T, Takeda M, Fujita Y, Nishie W, Akiyama M, Ishida-Yamamoto A, Shimizu H:
     Somatic recombination underlies frequent revertant mosaicism in loricrin keratoderma.
     Life Sci Alliance 2: e201800284, 2019
  7. Katayama S, Nomura T, Takeda M, Miyauchi T, Suzuki S, Peh JT, Nohara T, Kitamura S, Hata H, Shimizu H:
     A Case of Malignant Melanoma Arising in Nagashima-type Palmoplantar Keratosis.
     Acta Derm Venereol 99: 1311-1312, 2019.
  8. Nomura T, Suzuki S, Miyauchi T, Takeda M, Shinkuma S, Fujita Y, Nishie W, Akiyama M, Shimizu H:
     Chromosomal inversions as a hidden disease-modifying factor for somatic recombination phenotypes.
     JCI Insight 3: e97595, 2018.
  9. Ohguchi Y, Nomura T, Suzuki S, Takeda M, Miyauchi T, Mizuno O, Shinkuma S, Fujita Y, Nemoto O, Ono K, McLean WHI, Shimizu H:
     Gentamicin-induced readthrough and nonsense-mediated mRNA decay of SERPINB7 nonsense mutant transcripts.
     J Invest Dermatol 138: 836-843, 2018.
  10. Kosumi H, Miyauchi T, Nomura T, Suzuki S, Ohguchi Y, Nomura A, Shimizu H:
      Diagnostic features of acquired dermal melanocytosis of the face and extremities: A case report and review of the literature.
      Clin Exp Dermatol 43: 806-809, 2018

  Publication Lists (PubMed)

• IMAFUKU Keisuke

  Assistant Professor

  Fields of specialty

  Skin cancer, Tight junction

  More

  Certification

  Board-Certified Dermatologist, Japanese Dermatological Association
  (October 2018, Certification No. 9534)

  Professional Societies

  Japanese Dermatological Association
  Japanese Society for Investigative Dermatology
  Japan Organization of Clinical Dermatologists
  Japanese Skin Cancer Society

  Education and professional experience

  2012 Mar          M.D., Hokkaido University School of Medicine
  2013-Apr           Residency at the Kitami Red Cross Hospital
  2014-Apr           Residency at Department of Dermatology, Faculty of Medicine, University of Hokkaido
  2015-Apr  　    Associate at the Department of Dermatology, Tokyo Metropolitan Cancer and Infectious Diseases Center.
  2016-APr            Associate at Department of Dermatology, Faculty of Medicine, University of Hokkaido
  2022-Mar          Ph.D., Department of Dermatology, Graduate School of Medicine, Hokkaido University
  2022-Apr       Assistant Professor, Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
  2023-Apr      Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig Maximilian University of Munich (Jens Waschke Lab)
  2025 Oct        Assistant Professor Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University

  Major Publications

  1. Imafuku K, Yanagi T, Yoshimoto N, Miyazawa H, Iwata H, Ujiie H:
     Multiple courses of steroid pulse therapy are required in treating acquired idiopathic generalized anhidrosis patients with a large anhidrotic area: A retrospective study of 28 cases.
     Australas J Dermatol 65: 55-58, 2024.
  2. Imafuku K, Iwata H, Natsuga K, Okumura M, Kobayashi Y, Kitahata H, Kubo A, Nagayama M, Ujiie H:
     Zonula occludens-1 distribution and barrier functions are affected by epithelial proliferation and turnover rates.
     Cell Prolif 56: e13441, 2023.
  3. Itamoto S, Imafuku K, Miyazawa H, Anan T, Matsumiya H, Endo D, Mitamura T, Ujiie H:
     Hand-foot syndrome histopathologically presenting eccrine squamous syringometaplasia due to pembrolizumab after lenvatinib treatment.
     J Cutan Pathol 50: 932-935, 2023.
  4. Kurosawa S, Imafuku K, Nakakubo S, Iwasaki S, Teshima T, Goto H, Ujiie H:
     Pseudotumor of the skin due to Mycobacterium genavense.
     Int J Infect Dis 134: 88-90, 2023.
     
  5. Imafuku K, Kamaguchi M, Natsuga K, Nakamura H, Shimizu H, Iwata H:
     Zonula occludens-1 demonstrates a unique appearance in buccal mucosa over several layers.
     Cell Tissue Res 384: 691-702,2021.
  6. Nakamura Y, Asai J, Igaki H, Inozume T, Namikawa K, Hayashi A, Fukushima S, Fujimura T, Ito T, Imafuku K, Tanaka R, Teramoto Y, Minagawa A, Miyagawa T, Miyashita A, Wada M, Koga H, Sugaya M:
     Japanese Dermatological Association Guidelines: Outlines of guidelines for cutaneous melanoma 2019.
     J Dermatol 47: 89-103, 2020.
  7. Imafuku K, Yoshino K, Yamaguchi K, Tsuboi S, Ohara K, Hata H:
     A case of successfully switching from nivolumab to vemurafenib with oral corticosteroids.
     J Dermatol 45: e156, 2018.
  8. Imafuku K, Iwata H, Kamaguchi M, Izumi K, Natsuga K, Ujiie H, Nishie W, Shimizu H:
     Autoantibodies of non-inflammatory bullous pemphigoid hardly deplete type XVII collagen of keratinocytes.
     Exp Dermatol 12: 1171-1174, 2017.
  9. Imafuku K Hata H, Kitamura S, Yanagi T, Shimizu H:
     Ultrasonographic findings can identify ‘pseudoprogression’ under nivolumab therapy.
     Br J Dermatol 177: 1726-1731, 2017.
  10. Imafuku K, Hata H, Yamaguchi Y, Inamura Y, Kitamura S, Yanagi T, Shimizu H:
      Modified Dufourmentel flap, easy to design and tailor to the defect.
      J Dermatol 1: 68-70, 2017.

  Publication Lists (PubMed)

Medical Staffs / Residents / Visiting Clinical Doctors

• UJIIE Inkin
• TANAKA Arisa
• YAMAGA Misako
• NAGATA Yuri
• NARUSE Satsuki
• SATO Soma
• WATANABE Yukako
• ASADA Shota
• KUTOMI Yurika
• SARATANI Akari
• TANAKA Ryo
• TSUCHIYA Natsuko
• HIGUCHI Kazuki
• MARUO Miho
• MURATA Tatsuya

Ph.D. Course Students

• PEH Jin Teng
• TAKEDA Masae
• SHIIYA Chihiro
• SEO Takashi
• KATAYAMA Sho
• MIYAMOTO Kodai
• KAWAMURA Takuya
• INAMURA Emi
• MIZUKAMI Takuya
• SHIMANO Mayuna
• KIMURA Ayame
• HIRANO Yoko
• HAYASHIBE Ruri
• TRAJKOVIC Gabriel
• ITAMOTO Sota
• KUROSAWA Suguru
• KATO Sora

Researchers

• YANAGI Teruki
• IZUMI Kentaro
• TOKUCHI Keiko

  1030

• MAEDA Takuya

Central Research Institute

• NAKAMURA Hideki

Researching Abroad

• KOSUMI Hideyuki
• MAI Yosuke
• MAI Shoko

Laboratory Technicians

• KATO Sora
• AZUMA Hiroko

Medical Secretaries

• ISHIKAWA Chieko
• HATAKEYAMA Miho

Secretaries

• INADA Keiko
• LEE Aeri
• TOSHIRO Naoko

On leave of absence

• TOYONAGA Ellen

Professor Emeritus

• OHKAWARA Akira

Visiting Professor

Assistant Adjunct Professors

• KUMAKIRI Masanobu
• MATSUMURA Kazuko
• SHIMIZU Satoko
• KODAMA Kazuo
• NAKAMURA Hiroyuki
• ITO Kei
• OTA Mitsuhito
• HOSHINA Daichi
• ANAN Takashi
• SUZUKI Shotaro
• FUJITA Yasuyuki
• FUJIMURA Yu
• HOTTA Moeko
• NOMURA Toshifumi
• IWATA Hiroaki
• ANDO Satomi
• KIKUCHI Kazuhiro
• MIYAZAWA Hajime　
• YAMAGUCHI Yasuyuki