Team Leader: Wataru Nishie,
Senior Associate Professor
Our team is doing research to elucidate the pathophysiology of cutaneous basement membrane proteins and disorders relating to their dysfunction. We mainly research transmembrane collagen XVII, also known as COL17, and the research ranges from analyzing the function of this protein to the genome editing of cultured cells and model animals. In 2017, Dr. Ellen Toyonaga elucidated the pathogenesis of liner IgA dermatosis (Toyonaga E, et al. J Invest Dermatol 137: 2552-9, 2017) and graduated from the Ph.D. course. She’s living in the U.S. with her husband, who’s studying there. Dr. Kentaro
Izumi, who established a “full-length BP180 ELISA” when he was a graduate student, has been studying in Lübeck, Germany, since October 2017. I think both of them are enjoying
life abroad. The full-length BP180 ELISA has contributed to diagnoses of bullous pemphigoid, mucous pemphigoid and other diseases that are associated with the oral administration of DPP4 inhibitors, which are diabetes medications.
The excellent lab tech Hiroko Azuma has been working on 414 specimens that we’ve had requests, from within and beyond Japan, to analyze. As a dermatologist, I’m gratified
that my research can contribute directly to clinical practice.
At this moment, there are fewer doctors on the team, but the Ph.D. course student Yosuke Mai will be joining us in April 2018. He’s been researching on the team since training as a 6thyear graduate student, and he’s obtained some new findings.
I’m looking forward to the days when we can research with him. For any medical students
who may be reading this report, why not join us for experiments in our lab? It’s sure to be fun.
Download 'Team Nishie' in the annual report 2018, (, 2 pages total: 1.20MB)