Autoimmune Blistering Diseases Team (Izumi)

Since September 1 2020, we have taken over the work of the Nishie team and are conducting protein function analysis, cultured cell, mouse genome editing, and elucidation of the pathophysiology of autoimmune blistering diseases. We are verifying the effects of DPP-4 inhibitors on the development of bullous pemphigoid (BP) and analyzing self-antigen-specific IgE and basophils in BP. Dr. Yosuke Mai, a graduate student, is working on a number of themes, including analysis of the pathophysiology of neutrophilic dermatosis. Dr. Shoko Mai is establishing a new detection and quantification system for DPP-4 inhibitor-related BP-specific autoantibodies and creating a new system that enables detection and quantification of mucosal pemphigoid autoantibodies. We are proceeding with research that will have a significant impact on the treatment of autoimmune blistering diseases. Nami Ikeshita, a technician, is conducting serum analysis for the diagnosis of autoimmune blistering diseases, including the full-length BP180 ELISA method, as well as providing daily experimental assistance. Since April 2021, Dr. Haruhisa Watanabe has been newly appointed from the dentistry department, and we have begun the analysis of cell death of epidermal keratinocytes in BP, and are very much looking forward to future developments.

Major research results since 2016


Laboratory Introduction