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Faculty |
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M.D.,Keio University School of Medicine in 1979
Ph.D., Keio University School of Medicine in 1985 |
Research interests:
Genetic diagnosis and gene therapy. Tissue engineering, Autoimmune diseases.Skin barrier and keratinization.
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Since he opened the genetic counseling clinic for skin diseases, a range of patients have been referred to him from all over the world. He is also engaged in prenatal diagnosis and therapeutic research into several disorders. . Recent research includes the production of novel animal models for epidermolysis bullosa, bullous pemphigoid, and ichthyosis.As a leader of five large dermatology research groups, Hokkaido University has been developing several novel therapeutic strategies for blistering diseases and abnormal keratinization. Professor Shimizu has published more than 300 peer review English articles.
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| M.D., Hokkaido University School of Medicine in 1994 |
Research interest: Severe type of drug eruption
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He studied the mechanisms of the severe types of drug eruption, which are induced by serum soluble factors.
Research interest: Regenerative medicine
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He studied the regenerative medicine, particularly focused on keratinocyte stem cell.
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| M.D., Dokkyo Medical University in 1995 |
Research interests:
Mohs micrographic surgery for non-melanoma skin cancer in Japan
Evaluation of Sentinel node biopsy for high risk skin cancer
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| M.D., Hirosaki University in 1995 |
Research interests: Autoimmune blistering skin diseases |
Main project is generating novel therapeutic methods using several disease model mice.
Research interests: Inherited blistering skin diseases (Epidermolysis Bullosa) |
Main project is generating novel therapeutic methods including gene, protein and cell therapies. |
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| M.D., HokkaidoUniversitySchool of Medicine in 1997 |
Research interest: Identification of causative gene of hereditary skin disorders
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Using genetical and molecular biological method, he investigated several hereditary skin disorders to clarify the causative gene. Recently, he identified the OSMR gene as the gene for familial primary localized cutaneous amyloidosis.
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| M.D., Hokkaido University School of Medicine in 2002. |
Research interest: The pathomechanisms of autoimmune blistering skin diseases |
Using active mouse models, he investigates the pathomechanisms of autoimmune blistering skin diseases, such as bullous pemphigoid or epidermolysis bullosa acquisita.
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M.D., Hokkaido University School of Medicine in 2002.
Ph.D., Hokkaido University Graduate School of Medicine
in 2009. |
Research interest: Readthrough therapy |
He has been developing small molecule drugs to rescue nonsense mutations in disease-causing genes in collaboration with Prof Irwin McLean at University of Dundee.
Research interest: 2. Atopic dermatitis and filaggrin gene mutation |
He has carried out mutation analysis of the gene encoding filaggrin (FLG) in patients with atopic dermatitis (AD) and shown that FLG mutations predispose to AD in the Japanese population. |
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M.D., Hokkaido University School of Medicine in 2002.
Ph.D., Hokkaido University Graduate School of Medicine
in 2010.
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Research interest: Cell therapies for congenital skin disorders |
Using disease-model mice, he investigates novel cell therapies for congenital sin disorders such as epidermolysis bullosa.
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M.D., Nara Medical University in 2004.
Ph.D., Hokkaido University Graduate School of Medicine in 2011. |
Research interest: Inherited skin disorders (epidermolysis bullosa, hypotrichosis congenita)
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He focuses on clarifying pathomechanisms and developing novel treatments using molecular biological technique.
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